Herpes Virus Type 8 (HHV8) antibody

Details for Product No. ABIN115219
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Antigen
Reactivity
Human Herpesvirus 8 (HHV-8)
(14)
Host
Rat
(6), (3), (3), (2)
Clonality (Clone)
Monoclonal ()
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(11), (5), (5), (2), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 0.5 mL
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Catalog No. ABIN115219
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Immunogen Recombinant protein corresponding to the latent nuclear antigen-1 molecule of HHV8.
Clone LN53
Isotype IgG2c
Specificity This antibody stains with ORF-73 of Human Herpesvirus 8 (HHV8). HHV8 is the likely etiological agent of Kaposi's sarcoma (KS). HHV8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity. Cellular Localization: Nuclear. Species Reactivity: Tested: Human.
Purification Purified
Alternative Name Herpes Virus Type 8 / HHV8
Background HHV8 has been found to be associated with three different diseases observed in AIDS patients, kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non- Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma.
Alternate names: HHV-8, KHSV
Application Notes Immunohistochemistry: Use at 1/25-1/50 dilution in an ABC method (30 to 60 minutes atroom temperature). Formalin fixed paraffin embedded tissue sections require high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended Positive Control: Kaposi's sarcoma. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Supplier Images
anti-Herpes Virus Type 8 (HHV8) antibody Cultured cells infected with HHV8 stained with HHV8 antibody
General Dupin, Fisher, Kellam et al.: "Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 8, pp. 4546-51, 1999 (PubMed).

Kellam, Bourboulia, Dupin et al.: "Characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8." in: Journal of virology, Vol. 73, Issue 6, pp. 5149-55, 1999 (PubMed).

Ablashi, Chatlynne, Whitman et al.: "Spectrum of Kaposi's sarcoma-associated herpesvirus, or human herpesvirus 8, diseases." in: Clinical microbiology reviews, Vol. 15, Issue 3, pp. 439-64, 2002 (PubMed).

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