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Integrin alpha M (ITGAM) antibody

Details for Product No. ABIN118145
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Antigen
Synonyms CR3, CR3A, MAC1, Cd11b, Ly-40, Mac-1, Mac-1a, CD11b/CD18, F730045J24Rik, CD11B, MAC-1, MAC1A, MO1A, SLEB6, C3bi
Reactivity
Human, Mouse (Murine), Rabbit
(325), (252), (64), (21), (19), (16), (13), (7), (5), (3), (2), (1), (1)
Host
Rat
(258), (224), (55), (7), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(94), (59), (51), (26), (14), (10), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(431), (109), (107), (68), (58), (40), (37), (34), (33), (31), (10), (6), (3), (2), (2), (1), (1), (1)
Pubmed 14 references available
Quantity 0.25 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN118145
401.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen T cell enriched splenocytes from B10 mice. Spleen cells from immunised DA rats were fused with cells of the NS1/1.Ag4.1 mouse myeloma cell line.
Clone M1-70
Isotype IgG2b
Specificity This antibody recognises the CD11b cell surface antigen (also known as the alpha M integrin chain or MAC-1). Clone M1/70.15 has been reported to block iC3b binding to its receptor (Ref.3). SM014A is recommended for this purpose.
Purification Ion Exchange Chromatography
Alternative Name CD11b
Background CD11b is a differentiation antigen expressed by granulocytes, monocytes, NK cells and tissue macrophages. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages.
Alternate names: CD11 antigen-like family member B, CR-3 alpha chain, CR3A, Cell surface glycoprotein MAC-1 subunit alpha, ITGAM, Integrin alpha-M, Leukocyte adhesion receptor MO1, MAC1, Neutrophil adherence receptor
NCBI Accession 10090
UniProt P05555
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Glia marker, CD Antigens, Surface Receptors of Immune Cells
Application Notes Immunoprecipitation. Immunohistochemistry on frozen sections. Immunohistochemistry on paraffin sections. Flow cytometry: 1/50. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: Clone M1/70.15 has been reported to block iC3b binding to its receptor. ABIN118139 is recommended for this purpose.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS 0.09% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Springer, Galfrè, Secher et al.: "Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens." in: European journal of immunology, Vol. 8, Issue 8, pp. 539-51, 1978 (PubMed).

Springer, Galfré, Secher et al.: "Mac-1: a macrophage differentiation antigen identified by monoclonal antibody." in: European journal of immunology, Vol. 9, Issue 4, pp. 301-6, 1979 (PubMed).

Beller, Springer, Schreiber: "Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor." in: The Journal of experimental medicine, Vol. 156, Issue 4, pp. 1000-9, 1983 (PubMed).

Whiteland, Nicholls, Shimeld et al.: "Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 43, Issue 3, pp. 313-20, 1995 (PubMed).

Welt, Edelman, Simon et al.: "Neutrophil, not macrophage, infiltration precedes neointimal thickening in balloon-injured arteries." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 20, Issue 12, pp. 2553-8, 2000 (PubMed).

Klingel, Schnorr, Sauter et al.: "beta2-microglobulin-associated regulation of interferon-gamma and virus-specific immunoglobulin G confer resistance against the development of chronic coxsackievirus myocarditis." in: The American journal of pathology, Vol. 162, Issue 5, pp. 1709-20, 2003 (PubMed).

Brochard, Combadière, Prigent et al.: "Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease." in: The Journal of clinical investigation, Vol. 119, Issue 1, pp. 182-92, 2009 (PubMed).

Guzowska-Nowowiejska, Fiedorowicz, Plader: "Cucumber, melon, pumpkin, and squash: are rules of editing in flowering plants chloroplast genes so well known indeed?" in: Gene, Vol. 434, Issue 1-2, pp. 1-8, 2009 (PubMed).

Galès, Conduché, Bernad et al.: "PPARγ controls Dectin-1 expression required for host antifungal defense against Candida albicans." in: PLoS pathogens, Vol. 6, Issue 1, pp. e1000714, 2010 (PubMed).

Terrando, Rei Fidalgo, Vizcaychipi et al.: "The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction." in: Critical care (London, England), Vol. 14, Issue 3, pp. R88, 2010 (PubMed).

Ferger, Campanelli, Reimer et al.: "Effects of mitochondrial dysfunction on the immunological properties of microglia." in: Journal of neuroinflammation, Vol. 7, pp. 45, 2010 (PubMed).

Chinnery, Ruitenberg, McMenamin: "Novel characterization of monocyte-derived cell populations in the meninges and choroid plexus and their rates of replenishment in bone marrow chimeric mice." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 9, pp. 896-909, 2010 (PubMed).

Redensek, Rathore, Berard et al.: "Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury." in: Glia, Vol. 59, Issue 4, pp. 603-14, 2011 (PubMed).

General Springer: "Adhesion receptors of the immune system." in: Nature, Vol. 346, Issue 6283, pp. 425-34, 1990 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN118145
401.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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