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CD11b antibody (AA 623-728)

ITGAM Reactivity: Human WB, ELISA, ICC Host: Mouse Monoclonal 3A10H5 unconjugated
Catalog No. ABIN1724905
  • Target See all CD11b (ITGAM) Antibodies
    CD11b (ITGAM) (Integrin alpha M (ITGAM))
    Binding Specificity
    • 16
    • 14
    • 10
    • 7
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 623-728
    Reactivity
    • 258
    • 168
    • 62
    • 33
    • 17
    • 17
    • 16
    • 14
    • 11
    • 7
    • 7
    • 5
    • 5
    • 2
    • 2
    • 1
    Human
    Host
    • 136
    • 105
    • 103
    • 4
    • 1
    • 1
    Mouse
    Clonality
    • 250
    • 96
    • 1
    Monoclonal
    Conjugate
    • 119
    • 37
    • 29
    • 26
    • 20
    • 10
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD11b antibody is un-conjugated
    Application
    • 260
    • 83
    • 76
    • 72
    • 59
    • 40
    • 35
    • 26
    • 22
    • 20
    • 13
    • 13
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E. coli.
    Clone
    3A10H5
    Isotype
    IgG1
    Top Product
    Discover our top product ITGAM Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Rhodes, Fürnrohr, Roberts, Tzircotis, Schett, Spector, Vyse: "The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes." in: Annals of the rheumatic diseases, Vol. 71, Issue 12, pp. 2028-34, (2012) (PubMed).

    Grüger, Reiners, Schnitzler, Brandenburg, Zündorf: "Garenoxacin-induced increase of CD11b expression on human polymorphonuclear neutrophils does not affect phagocytosis and killing of Staphylococcus aureus." in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Vol. 17, Issue 2, pp. 291-6, (2011) (PubMed).

  • Target
    CD11b (ITGAM) (Integrin alpha M (ITGAM))
    Alternative Name
    ITGAM (ITGAM Products)
    Synonyms
    CD11b/CD18 antibody, CR3 antibody, CR3A antibody, Cd11b antibody, F730045J24Rik antibody, Ly-40 antibody, MAC1 antibody, Mac-1 antibody, Mac-1a antibody, CD11B antibody, MAC-1 antibody, MAC1A antibody, MO1A antibody, SLEB6 antibody, C3bi antibody, integrin subunit alpha M antibody, integrin alpha M antibody, integrin, alpha M (complement component 3 receptor 3 subunit) antibody, integrin alpha-M antibody, ITGAM antibody, Itgam antibody, LOC100351865 antibody
    Background

    Description: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. ,

    Aliases: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6

    Molecular Weight
    127.1 kDa
    Gene ID
    3684
    HGNC
    3684
    Pathways
    Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
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