CD11b antibody (AA 145-340)

Catalog No. ABIN3022180

Cited in 1 publication. The Rabbit Polyclonal anti-CD11b antibody (ABIN3022180) specifically detects CD11b in IHC, WB and IF. The antibody is reactive with Human samples.

Quick Overview for CD11b antibody (AA 145-340) (ABIN3022180)

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD11b antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-CD11b Antibody

Binding Specificity: AA 145-340

Sequence: PQEDSDIAFL IDGSGSIIPH DFRRMKEFVS TVMEQLKKSK TLFSLMQYSE EFRIHFTFKE FQNNPNPRSL VKPITQLLGR THTATGIRKV VRELFNITNG ARKNAFKILV VITDGEKFGD PLGYEDVIPE ADREGVIRYV IGVGDAFRSE KSRQELNTIA SKPPRDHVFQ VNNFEALKTI QNQLREKIFA IEGTQT

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 145-340 of CD11b/ITGAM (NP_000623.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-CD11b antibody (ABIN3022180)

Wang, Zheng, Gu, Cai, Wang, Zhang, Chen, Situ, Lin, Wang: "Network-pharmacology-based validation of TAMS/CXCL-1 as key mediator of XIAOPI formula preventing breast cancer development and metastasis." in: Scientific reports, Vol. 7, Issue 1, pp. 14513, (2017) (PubMed).

Target Details for CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Alternative Name: ITGAM

Background: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.,CD11B,CR3A,MAC-1,MAC1A,MO1A,SLEB6,ITGAM,CD11b/ITAM,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,PI3K-Akt Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Immunology & Inflammation,CD markers,Neuroscience,Cell Type Marker,Stem Cells,Hematopoietic Progenitors,Mesenchymal Stem Cells,Microglia marker,ITGAM

Molecular Weight: 127 kDa

Gene ID: 3684

UniProt: P11215

Pathways: Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation