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LAT2 antibody (Linker For Activation of T Cells Family, Member 2) (AA 91-244)

Details for Product anti-LAT2 Antibody No. ABIN120727, Supplier: Login to see New
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Synonyms BG:DS00004.9, CG1264, Dm lab, DmLab, Dmel\\CG1264, Dmlab, EfR9, F121, F24, F90, F90-2, Lab, l(3)01241, l(3)84Ac, lb, LAT2, MGC139435, LAB, NTAL, WBSCR15, WBSCR5, WSCR5, AW125574, Wbscr15, Wbscr5, Ntal
AA 91-244
(16), (16), (16), (13), (12), (10), (10), (6), (6), (5), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1)
Human, Mouse (Murine)
(95), (21), (15), (4), (2)
(80), (29), (10)
Clonality (Clone)
Monoclonal ()
This LAT2 antibody is un-conjugated
(8), (6), (5), (3), (3), (3), (1)
Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(104), (42), (24), (17), (17), (12), (8), (6), (3), (2), (2), (1)
Pubmed 1 reference available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant cytoplasmic domain (aa 91-244) of human NTAL
Clone NAP-07
Isotype IgG1
Specificity The antibody reacts with Non-T cell activation linker (NTAL), also known as LAB (linker of activated B cells), a 25 - 30 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B lymphocytes, NK cells and myeloid cells.
Purification Protein A affinity chromatography
Purity > 95 % (by SDS-PAGE)
Alternative Name LAT2 / WBSCR15 (LAT2 Antibody Abstract)
Background NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.Synonyms: HSPC046, LAB, LLinker for activation of B-cells, Linker for activation of T-cells family member 2, Membrane-associated adapter molecule, NTAL, Non-T-cell activation linker, WBS15, WBSCR5, Williams-Beuren syndrome chromosomal region 15 protein
Gene ID 7462
UniProt Q9GZY6
Pathways Fc-epsilon Receptor Signaling Pathway
Application Notes Immunoprecipitation. Western Blot: Recommended dilution: 2 mg/mL, incubation 60 min Positive control: RAMOS human lymphoma cell line Negative control: HeLa human cervix carcinoma cell line Sample preparation: Resuspend approx. 50 mil. cells in 1 mLcold Lysis buffer (1 % laurylmaltoside in 20 mM Tris/Cl, 100 mM NaCl pH 8.2, 50 mM NaF including Protease inhibitor Cocktail). Incubate 60 min on ice. Centrifuge to remove cell debris. Mix lysate with non- reducing SDS-PAGE sample buffer. Application note: Non-Reducing conditions. 12 % separating SDS-PAGE gel. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Background publications Brdicka, Imrich, Angelisová et al.: "Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling." in: The Journal of experimental medicine, Vol. 196, Issue 12, pp. 1617-26, 2002 (PubMed).

Catalog No. ABIN120727
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