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Details for Product No. ABIN120728

Linker For Activation of T Cells Family, Member 2 (LAT2) (AA 196-212) antibody

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Antigen
Synonyms BG:DS00004.9, CG1264, Dm lab, DmLab, Dmel\\CG1264, Dmlab, EfR9, F121, F24, F90, F90-2, Lab, l(3)01241, l(3)84Ac, lb, LAB, NTAL, WBSCR15, WBSCR5, WSCR5, Ntal, Wbscr5, AW125574, Wbscr15, LAT2, MGC139435
Epitope
»Alternatives AA 196-212
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 1 reference available
Catalog no. ABIN120728
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide corresponding to aa 196-212 of human NTAL coupled to KLH
Clone NAP-03
Isotype IgG1
Purification Protein A affinity chromatography
Purity > 95 % (by SDS-PAGE)
Alternative Name LAT2 / WBSCR15
Background NTAL (Non-T cell Activation Linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
UniProt Q9GZY6
Application Notes Immunoprecipitation. Western Blot: Recommended dilution: 1-2 mg/ml, incubation 60 min. Positive control: RAMOS human lymphoma cell line. Sample preparation: Resuspend approx. 50 mil. cells in 1 ml cold Lysis buffer (1% laurylmaltoside in 20 mM Tris/Cl, 100 mM NaCl pH 8.2, 50 mM NaF including Protease inhibitor Cocktail). Incubate 60 min on ice. Centrifuge to remove cell debris. Mix lysate with non- reducing SDS-PAGE sample buffer. Application note: Non-Reducing conditions. 12% separating SDS-PAGE gel. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Brdicka, Imrich, Angelisová et al.: "Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling." in: The Journal of experimental medicine, Vol. 196, Issue 12, pp. 1617-26, 2002 (PubMed).

Alternatives for antigen "Linker For Activation of T Cells Family, Member 2 (LAT2)", type "Antibodies"
Hosts (48), (35), (2)
Reactivities (70), (18), (5), (1), (1), (1), (1), (1), (1)
Applications (63), (29), (28), (16), (12), (10), (10), (9), (4), (1), (1), (1)
Conjugates (7), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (20), (10), (9), (7), (6), (3), (3), (3), (2), (2), (2), (1), (1)
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