Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody

Details for Product No. ABIN127050
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Antigen
Synonyms MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, Tkr, trk, TrkA, C80751, Trk, CTRKA, trkA, trka
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(258), (168), (163), (29), (29), (12), (12), (1)
Host
Rabbit
(249), (19), (3), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (2), (1), (1), (1), (1), (1), (1)
Application
Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(154), (119), (60), (57), (40), (32), (30), (24), (15), (4), (3), (1)
Pubmed 2 references available
Catalog no. ABIN127050
Quantity 0.1 mg
Price
368.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide surrounding amino acid 494 of human TrkA
Specificity The antibody detects 140 kDa TrkA. It does not cross-react with TrkB or TrkC.
Purification Affinity Chromatography
Alternative Name TrkA
Background TrkA, the high affinity Nerve Growth Factor (NGF) receptor, autophosphorylates on tyrosine to activate multiple effectors. Phosphorylation at Tyr490 is required for Shc association and activation of the Ras-MAP kinase cascade. Residues Tyr674/675 lie within the catalytic domain, and phosphorylation at these sites reflects Trk kinase activity.
Alternate names: High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1-transforming tyrosine kinase protein, Trk-A, p140-TrkA
Gene ID 4914
NCBI Accession NP_001007793.1
UniProt P04629
Research Area Cancer
Application Notes Western blotting (0.5-4 μg/ml). Immunoprecipitation. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, pH 7.2, containing 30% Glycerol, 0.5% BSA, 0.01% Thimerosal.
Preservative Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody at -20°C. For long-term storage, aliquot and freeze at -20°C to -70°C.
Expiry Date 12 months
Supplier Images
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody
General Stephens, Loeb, Copeland et al.: "Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses." in: Neuron, Vol. 12, Issue 3, pp. 691-705, 1994 (PubMed).

Segal, Greenberg: "Intracellular signaling pathways activated by neurotrophic factors." in: Annual review of neuroscience, Vol. 19, pp. 463-89, 1997 (PubMed).

Hosts (249), (19), (3), (2)
Reactivities (258), (168), (163), (29), (29), (12), (12), (1)
Applications (154), (119), (60), (57), (40), (32), (30), (24), (15), (4), (3), (1)
Conjugates (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (2), (1), (1), (1), (1), (1), (1)
Epitopes (28), (23), (16), (16), (15), (15), (13), (12), (12), (12), (12), (12), (12), (12), (10), (8), (7), (7), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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