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Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody

Antigen

Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1)
Synonyms MTC, TRK, TRK1, TRKA, p140-TrkA, DKFZp781I14186, Tkr, trk, TrkA, C80751, trka, Trk, NTRK1, trkA, CTRKA
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
2 references available
Catalog no. ABIN127050
Quantity 0.1 mg  (0.5 mg/ml)  (Variants)
Price 319.00 $   Plus shipping costs $45.00
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anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody

Additional Information
Application Details Publications Images Alternatives Variants back to top

Alternative name TrkA
UniProt P04629
Immunogen Synthetic peptide surrounding amino acid 494 of human TrkA
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Description TrkA, the high affinity Nerve Growth Factor (NGF) receptor, autophosphorylates on tyrosineto activate multiple effectors. Phosphorylation at Tyr490 is required for Shc associationand activation of the Ras-MAP kinase cascade. Residues Tyr674/675 lie within the catalyticdomain, and phosphorylation at these sites reflects Trk kinase activity.
Characteristics Synonyms: NTRK1, TRK, Trk-A, High affinity nerve growth factor receptor, Neurotrophic tyrosine kinasereceptor type 1, TRK1-transforming tyrosine kinase protein, p140-TrkA

Application Details
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Application Notes Western blotting (0.5-4 μg/ml). Immunoprecipitation. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Concentration 0.5 mg/ml
Purification Purified
Buffer PBS, pH 7.2, containing 30% Glycerol, 0.5% BSA, 0.01% Thimerosal.
Storage Store the antibody at -20°C. For long-term storage, aliquot and freeze at -20°C to -70°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Research Area Cancer
Restrictions For Research Use only

Publications
Application Details Images Alternatives Variants back to top

Stephens, Loeb, Copeland et al.: "Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses." in: Neuron, Vol. 12, Issue 3, pp. 691-705, 1994 (PubMed).

Segal, Greenberg: "Intracellular signaling pathways activated by neurotrophic factors." in: Annual review of neuroscience, Vol. 19, pp. 463-89, 1997 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1)", type "Antibodies"
Hosts Rabbit (176), Mouse (16), Goat (3), Sheep (1)
Reactivities Human (184), Rat (Rattus) (117), Mouse (Murine) (113)
Applications Western Blotting (WB) (106), ELISA (86), Immunofluorescence (IF) (85), Immunohistochemistry (IHC) (26), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (26), Immunoprecipitation (IP) (24), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (15), Immunocytochemistry (ICC) (11), Flow Cytometry (FACS) (9), Immunoelectron Microscopy (IEM) (5), Immunohistochemistry (Fixed) (IHC (fx)) (5), Dot Blot (Dot) (2), Neutralization (Neut) (1)
Conjugates PE (6), Biotin (5), Cy3 (5), Cy5 (5), Cy5.5 (5), Cy7 (5), FITC (5), Gold (5), HRP (5), PE,Cy3 (4), PE,Cy5 (4), PE,Cy7 (4), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), APC (1), PE,Cy5.5 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1)
Epitopes pSer791 (24), C-Term (23), pTyr490 (16), pTyr674,pTyr675 (13), pTyr785 (13), Extracellular Domain (9), Internal Region (8), pTyr791 (7), Middle Region,Internal Region (3), pTyr496,Internal Region (3), pTyr676 (3), pTyr680,pTyr681,C-Term (3), pTyr680,pTyr681,Internal Region (3), pTyr701,C-Term (3), Center (2), Extracellular Domain, N-Term (2), Ser791 (2), Tyr791 (2), pTyr680, pTyr681 (2), Arg220 (1), C-Term,Leu784 (1), Cytoplasmic Domain (1), N-Term (1), Phosphospecific (1), pTyr496 (1), pTyr701 (1), pTyr757 (1)