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Details for Product No. ABIN135738

Integrin alpha M (ITGAM) antibody (RPE)

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Antigen
Synonyms CR3, CR3A, MAC1, Cd11b, Ly-40, Mac-1, Mac-1a, CD11b/CD18, F730045J24Rik, CD11B, MAC-1, MAC1A, MO1A, SLEB6, C3bi
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
Application
»Alternatives Flow Cytometry (FACS), Immunohistochemistry (IHC)
Pubmed 2 references available
Catalog no. ABIN135738
Quantity 100 tests
Price
250.80 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Clone ICRF44
Isotype IgG1
Characteristics The antibody detects: Human CD11b/Mac-1
Alternative Name CD11b/Mac-1a
Background CD11b is the 165 kDa M chain which combines with the CD18 2 integrin subunit to form the Mac-1 heterodimer. It is expressed on activated lymphocytes, monocytes, granulocytes and a subset of NK cells. CD11b/Mac-1 functions in cell-cell and cell-substrate interactions and is a ligand for C3bi, CD50 (ICAM-3), CD54 (ICAM-1) and CD102 (ICAM-2).
Application Notes Working Dilution:
FACS: 2 µL/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Comment

Blocking Studies

Restrictions For Research Use only
Buffer Product is supplied as 100 tests in 1.0 mL of PBS / NaN3 and a stabilizing agent.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Do not freeze!
Protect conjugated products from light.

Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage 4 °C
Springer: "Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm." in: Cell, Vol. 76, Issue 2, pp. 301-14, 1994 (PubMed).

Lee, Bankston, Arnaout et al.: "Two conformations of the integrin A-domain (I-domain): a pathway for activation?" in: Structure (London, England : 1993), Vol. 3, Issue 12, pp. 1333-40, 1996 (PubMed).

Alternatives for antigen "Integrin alpha M (ITGAM)", type "Antibodies"
Hosts (154), (125), (30), (4), (2)
Reactivities (155), (126), (25), (9), (6), (5), (4), (3), (3), (3), (1), (1), (1), (1)
Applications (251), (70), (44), (41), (36), (33), (28), (26), (13), (11), (9), (3), (3), (2), (1), (1), (1)
Conjugates (44), (32), (32), (10), (9), (8), (4), (4), (3), (2), (2), (2), (1), (1)
Epitopes (3), (3), (1), (1), (1), (1), (1), (1)
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