CD40 antibody

Catalog No. ABIN1383854

Product Details anti-CD40 Antibody

Target: CD40

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD40 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Functional Studies (Func)

Specificity: Recognises the Bp50 antigen, a 48 kDa protein

Purification: Ion exchange chromatography

Sterility: 0.22 μm filtered

Immunogen: Raji cell line,Myeloma X63/AG.8653 x Balb/c spleen cells

Clone: B-B20

Isotype: IgG1 kappa

Biological Activity Comment: Stimulates B-cell proliferation together with IL-4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

References for anti-CD40 antibody (ABIN1383854)

de Goër de Herve, Durali, Tran, Maigné, Simonetta, Leclerc, Delfraissy, Taoufik: "Differential effect of agonistic anti-CD40 on human mature and immature dendritic cells: the Janus face of anti-CD40." in: Blood, Vol. 106, Issue 8, pp. 2806-14, (2005) (PubMed).

Durali, de Goër de Herve, Giron-Michel, Azzarone, Delfraissy, Taoufik: "In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment." in: Blood, Vol. 102, Issue 12, pp. 4084-9, (2003) (PubMed).

Puig-Kröger, Relloso, Fernández-Capetillo, Zubiaga, Silva, Bernabéu, Corbí: "Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells." in: Blood, Vol. 98, Issue 7, pp. 2175-82, (2001) (PubMed).

Jeannin, Delneste, Lecoanet-Henchoz, Gauchat, Ellis, Bonnefoy: "CD86 (B7-2) on human B cells. A functional role in proliferation and selective differentiation into IgE- and IgG4-producing cells." in: The Journal of biological chemistry, Vol. 272, Issue 25, pp. 15613-9, (1997) (PubMed).

Target Details for CD40

Target: CD40

Alternative Name: CD40 (CD40 Products)

Molecular Weight: 48 kDa

Pathways: NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints