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Ion Channels

Ion channels are pore-forming proteins that allow the flow of ions across membranes, either plasma membranes or the membranes of intracellular organelles. Many ion channels (such as most Na, K Ca and some Cl channels) are gated by voltage but others (such as certain K and Cl channels, TRP channels, ryanodine receptors and IP3 receptors) are relatively voltage-insensitive and are gated by second messengers and other intracellular and/or extracellular mediators.(1)

Most ion channels are highly selective for the class of ions crossing the channel. They can therefore be easily classified into sodium channels, calcium channels, potassium channels, proton channels or non-selective cation channels. Research on ion channels requires a large number of methods and materials. We offer monoclonal and polyclonal antibodies, ELISA kits and high-quality made-to-order proteins for this complex topic.

Aquaporins

Aquaporins (often called aquaporin water channels) are a family of small, integral membrane proteins that are expressed broadly throughout the animal and plant kingdoms. They have a similar basic structure, with aquaporin monomers consisting of six transmembrane helical segments and two short helical segments that surround cytoplasmic and extracellular vestibules connected by a narrow aqueous pore.(2)

To search our Aquaporin antibodies, kits, proteins click on the links below.

Calcium Channels

A calcium channel is a transmembrane ion channel that is permeable to calcium ions. The permeability is controlled either by voltage-gated calcium channels or ligand-gated calcium channels. We offer some hand-picked monoclonal and polyclonal antibodies for research on calcium channels.

Product
Reactivity
Clonality
Application
Cat. No.
Quantity
ReactivityHuman, Mouse, Rat
ClonalityMonoclonal
ApplicationICC, IF, IP, IHC, WB
Cat. No.ABIN1721482
Quantity100 μg
ReactivityHuman, Mouse, Rabbit, Rat
ClonalityMonoclonal
ApplicationICC, FACS, IF, IP, IHC, WB
Cat. No.ABIN1721483
Quantity100 μg
ReactivityHuman, Mouse, Rat
ClonalityMonoclonal
ApplicationIHC, WB
Cat. No.ABIN1098196
Quantity100 μg
ReactivityRat
ClonalityMonoclonal
ApplicationFM, IHC, IP, WB
Cat. No.ABIN6658066
Quantity100 μg
ReactivityMammalian
ClonalityMonoclonal
ApplicationISt, IHC, WB
Cat. No.ABIN1304586
Quantity5 mL
ReactivityHuman, Mouse, Rat
ClonalityMonoclonal
ApplicationICC, IF, IHC, WB
Cat. No.ABIN1721488
Quantity100 μg
ReactivityHuman, Mouse
ClonalityPolyclonal
ApplicationICC, IF, IHC (p), WB
Cat. No.ABIN2854649
Quantity100 μL
ReactivityMammalian
ClonalityMonoclonal
ApplicationISt, IHC, WB
Cat. No.ABIN1304590
Quantity5 mL

See all Calcium Channel Antibodies

Potassium Channels

Potassium channels ubiquitously exist in nearly all kingdoms of life and perform diverse but important functions. Since the first atomic structure of a prokaryotic potassium channel (KcsA, a channel from Streptomyces lividans) was determined, tremendous progress has been made in understanding the mechanism of potassium channels and channels conducting other ions.(3)

Product
Reactivity
Clonality
Application
Cat. No.
Quantity
ReactivityMouse
ClonalityMonoclonal
ApplicationIHC, IP, WB
Cat. No.ABIN6657685
Quantity100 μg
ReactivityMouse
ClonalityMonoclonal
ApplicationFM, IHC, IP, WB
Cat. No.ABIN6657686
Quantity100 μg
ReactivityHuman, Mouse, Rat
ClonalityMonoclonal
ApplicationICC, FACS, IF, IP, IHC, WB
Cat. No.ABIN1721589
Quantity100 μg
ReactivityHuman, Mouse, Rat
ClonalityMonoclonal
ApplicationICC, FACS, IF, IP, IHC, WB
Cat. No.ABIN1721590
Quantity100 μg
ReactivityCow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat, Sheep
ClonalityPolyclonal
ApplicationWB
Cat. No.ABIN2776142
Quantity100 μL
ReactivityHuman
ClonalityMonoclonal
ApplicationFACS, ELISA, WB
Cat. No.ABIN969227
Quantity100 μL
ReactivityHamster, Human, Mouse, Rat
ClonalityMonoclonal
ApplicationAA, ICC, IF, IHC, IP, WB
Cat. No.ABIN2482775
Quantity100 μg
ReactivityHuman, Mouse, Pig, Rat
ClonalityPolyclonal
ApplicationELISA
Cat. No.ABIN570733
Quantity100 μg
ReactivityHuman, Mouse
ClonalityPolyclonal
ApplicationELISA, WB
Cat. No.ABIN3185286
Quantity100 μL

Sodium Channels

There are two major classes of sodium channels in mammals: The voltage-gated sodium channel (VGSC) family and the epithelial sodium channel (ESC). Voltage-gated sodium channels exist throughout the body in various cell types, while epithelial sodium channels are located primarily in the skin and kidney.(4)

Product
Reactivity
Clonality
Application
Cat. No.
Quantity
ReactivityCow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
ClonalityPolyclonal
ApplicationWB
Cat. No.ABIN2776229
Quantity100 μL
ReactivityHamster, Human, Mouse, Rat, Xenopus laevis
ClonalityPolyclonal
ApplicationICC, IF, IHC, WB
Cat. No.ABIN863204
Quantity100 μg
ReactivityHuman, Mouse, Rat
ClonalityPolyclonal
ApplicationIF (p), IHC (p), WB
Cat. No.ABIN713471
Quantity100 μL
ReactivityHamster, Human, Mouse, Rat, Xenopus laevis
ClonalityPolyclonal
ApplicationICC, IF, IHC, WB
Cat. No.ABIN2486428
Quantity100 μg
ReactivityHuman
ClonalityPolyclonal
ApplicationELISA, WB
Cat. No.ABIN565642
Quantity50 μL
ReactivityHuman, Mouse, Rat
ClonalityMonoclonal
ApplicationICC, IF, WB
Cat. No.ABIN2483030
Quantity100 μg

TRP

Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis.(5)

Product
Reactivity
Clonality
Application
Cat. No.
Quantity
ReactivityHuman, Mouse, Rat
ClonalityPolyclonal
ApplicationIHC, WB
Cat. No.ABIN351117
Quantity100 μL
ReactivityHuman, Mouse, Rat
ClonalityMonoclonal
ApplicationAA, IHC, IP, WB
Cat. No.ABIN2485379
Quantity100 μg
ReactivityHuman, Chimpanzee
ClonalityMonoclonal
ApplicationIHC, ELISA, WB
Cat. No.ABIN964697
Quantity100 μg
ReactivityDog, Human, Monkey
ClonalityMonoclonal
ApplicationIHC, WB
Cat. No.ABIN2725815
Quantity0.1 mL
ReactivityHuman
ClonalityPolyclonal
ApplicationEIA, IHC (p), WB
Cat. No.ABIN4620541
Quantity0.1 mg

See all TRP-related Antibodies

Cyclic Nucleotide-gated Ion Channels

Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in retinal photoreceptors and olfactory sensory neurons (OSNs). They are opened by the direct binding of cyclic nucleotides, cAMP and cGMP. Although their activity shows very little voltage dependence, CNG channels belong to the superfamily of voltage-gated ion channels.(6) Below you will find a selection of polyclonal antibodies against CNG ion channels.

Product
Reactivity
Clonality
Application
Cat. No.
Quantity
ReactivityHuman
ClonalityPolyclonal
ApplicationICC, IF, IHC (p), WB
Cat. No.ABIN2856869
Quantity100 μL
ReactivityHuman
ClonalityPolyclonal
ApplicationWB
Cat. No.ABIN1679299
Quantity100 μg
ReactivityMouse
ClonalityPolyclonal
ApplicationIHC (p), WB
Cat. No.ABIN5532896
Quantity400 μL
ReactivityHuman
ClonalityPolyclonal
ApplicationWB
Cat. No.ABIN5619308
Quantity100 μL

See all CNG ion channel Antibodies

Hyperpolarization-activated Cyclic Nucleotide-gated Channels (HCN)

A hyperpolarization-activated cyclic nucleotide-gated channel (HCN) is a subtype of CNG channel that is gated by hyperpolarization of the cell membrane. There are four HCN channels HCN1, HCN2, HCN3, and HCN4.

Product
Reactivity
Clonality
Application
Cat. No.
Quantity
ReactivityHuman, Mouse, Rat
ClonalityMonoclonal
ApplicationAA, IHC, IP, WB
Cat. No.ABIN2483966
Quantity100 μg
ReactivityRat
ClonalityMonoclonal
ApplicationFM, IHC, IP, WB
Cat. No.ABIN6658118
Quantity100 μg
ReactivityHuman, Mouse, Rat
ClonalityMonoclonal
ApplicationAA, ICC, IF, IHC, WB
Cat. No.ABIN2483847
Quantity100 μg
ReactivityHuman, Mouse, Rat
ClonalityPolyclonal
ApplicationIF (p), IHC (p), WB
Cat. No.ABIN733043
Quantity100 μL

See all HCN ion channel Antibodies

We offer you Made-to-order Channel Proteins

We offer high-purity made-to-order ion channel proteins with native state folding guarantee. Below you will find a selection of potassium channel proteins. Please contact us via email, chat, or phone for more information about our made-to-order proteins.

Product
Protein Type
Conjugate
Cat. No.
Quantity
Protein TypeRecombinant
ConjugateHis tag
Cat. No.ABIN3077909
Quantity1 mg
Protein TypeRecombinant
ConjugateHis tag
Cat. No.ABIN3081371
Quantity1 mg
Protein TypeRecombinant
Conjugaterho-1D4 tag
Cat. No.ABIN3093343
Quantity0.5 mg
Protein TypeRecombinant
ConjugateHis tag
Cat. No.ABIN3130433
Quantity1 mg

References:

  • (1) Ion Channels. Br J Pharmacol. 2011 Nov;164(Suppl 1):S137–S174. doi: 10.1111/j.1476-5381.2011.01649_5.x. PMCID: PMC3315630.
  • (2) Verkman AS. Aquaporins. Curr Biol. 2013 Jan 21;23(2):R52-5. doi: 10.1016/j.cub.2012.11.025. PMID: 23347934; PMCID: PMC3590904.
  • (3) Kuang Q, Purhonen P, Hebert H. Structure of potassium channels. Cell Mol Life Sci. 2015 Oct;72(19):3677-93. doi: 10.1007/s00018-015-1948-5. Epub 2015 Jun 13. PMID: 26070303; PMCID: PMC4565861.
  • (4) Hernandez CM, Richards JR. Physiology, Sodium Channels. [Updated 2019 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545257/
  • (5) Dhakal S, Lee Y. Transient Receptor Potential Channels and Metabolism. Mol Cells. 2019 Aug 31;42(8):569-578. doi: 10.14348/molcells.2019.0007. PMID: 31446746; PMCID: PMC6715338.
  • (6) Kaupp UB, Seifert R. Cyclic nucleotide-gated ion channels. Physiol Rev. 2002 Jul;82(3):769-824.
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