TLR4 antibody (PE)

Catalog No. ABIN1449236

Product Details anti-TLR4 Antibody (PE)

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This TLR4 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: This antibody reacts with mouse TLR4/MD-2 complex.

Purification: Protein A agarose

Immunogen: Mouse TLR4/MD-2 transfected Ba/F3 cell

Clone: UT15

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: 50 tests in 1 mLPBS containing 1 % BSA and 0.09 % NaN3

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8 °C.

Target Details for TLR4

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Alternative Name: CD284 / TLR4 (TLR4 Products)

Background: Toll, a Drosophila receptor molecule with extracellular leucine-rich repeat (LRR), has a role in triggering innate defenses against bacteria or fungi. TLR4 (Toll-like receptor 4) is a member of TLR family, which is human homologue of Toll protei n. It has extracellular LRR and an intracellular signaling domain, which is similar to the type I IL-1 receptor. TLR4 is expressed in subpopulations of cells including myeloid cells, B cells, monocytes, and endothelial cells. Recent studies have suggested that TLR4 might act as a receptor for LPS (lipopolysaccharide). TLR4 alone is not capable of sensing and signaling the presence of LPS, but another molecule MD-2, which is physically associated with TLR4, is required for LPS recognition through TLR4.Synonyms: Toll-like receptor 4

Gene ID: 21898

NCBI Accession: NP_067272

UniProt: Q9QUK6

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins