PHOX2A antibody (C-Term)

Catalog No. ABIN1449933

This anti-PHOX2A antibody is a Rabbit Polyclonal antibody detecting PHOX2A in WB, IF, IHC (p) and EIA. Suitable for Human, Rat and Mouse.

Quick Overview for PHOX2A antibody (C-Term) (ABIN1449933)

Target: PHOX2A (Paired-Like Homeobox 2a (PHOX2A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHOX2A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-PHOX2A Antibody

Binding Specificity: C-Term

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid synthetic peptide near the carboxy terminus of Human PHOX2A

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PHOX2A

Target: PHOX2A (Paired-Like Homeobox 2a (PHOX2A))

Alternative Name: PHOX2A

Background: PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.Synonyms: ARIX, ARIX1 homeodomain protein, Aristaless homeobox protein homolog, PMX2A, Paired mesoderm homeobox protein 2A, Paired-like homeobox 2A

Gene ID: 401

NCBI Accession: NP_005160