Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) (N-Term) antibody

Details for Product No. ABIN1449989
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Synonyms DFNB48, KIP2, USH1J, Kip2, p57, p57KIP2, cb961, p27Xic1-a, zgc:86618, BWCR, BWS, WBS, p57Kip2, AL024410, CDKI, p57(kip2)
(32), (20), (18), (12), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(152), (50), (31), (3), (1), (1), (1)
(113), (48)
(7), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(86), (52), (43), (39), (32), (20), (15), (6), (3), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN1449989
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Immunogen A 17 amino acid synthetic peptide near the amino terminus of Human CDKN1C
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name CDKN1C / KIP2
Background The cyclin-dependent kinase inhibitor 1C (CDKN1C), also known as p57KIP2, is a tight-binding, strong inhibitor of several G1 cyclin/CDK complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndrome, a cancer-predisposing syndrome, suggesting that this gene is a tumor suppressor candidate. CDKN1C is widely expressed during organogenesis with its expression declining after maturity. It is part of the CIP/KIP family of cyclin-dependent inhibitors (CKIs) which also includes CDKN1A and CDKN1B.Synonyms: Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57KIP2
Molecular Weight 35 kDa
Gene ID 1028
NCBI Accession NP_000067
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Pateras, Apostolopoulou, Niforou et al.: "p57KIP2: \Kip\"ing the cell under control."" in: Molecular cancer research : MCR, Vol. 7, Issue 12, pp. 1902-19, 2009 (PubMed).

Hatada, Ohashi, Fukushima et al.: "An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome." in: Nature genetics, Vol. 14, Issue 2, pp. 171-3, 1996 (PubMed).

Lee, Reynisdóttir, Massagué: "Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution." in: Genes & development, Vol. 9, Issue 6, pp. 639-49, 1995 (PubMed).

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