Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) (N-Term) antibody

Details for Product No. ABIN1449989
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Antigen
Synonyms DFNB48, KIP2, USH1J, Kip2, p57, p57KIP2, cb961, p27Xic1-a, zgc:86618, BWCR, BWS, WBS, p57Kip2, AL024410, CDKI, p57(kip2)
Epitope
N-Term
(26), (18), (13), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(133), (48), (31), (13), (4), (1)
Host
Rabbit
(101), (40)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(74), (45), (43), (29), (25), (20), (14), (6), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN1449989
401.50 $
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Immunogen A 17 amino acid synthetic peptide near the amino terminus of Human CDKN1C
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name CDKN1C / KIP2
Background The cyclin-dependent kinase inhibitor 1C (CDKN1C), also known as p57KIP2, is a tight-binding, strong inhibitor of several G1 cyclin/CDK complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndrome, a cancer-predisposing syndrome, suggesting that this gene is a tumor suppressor candidate. CDKN1C is widely expressed during organogenesis with its expression declining after maturity. It is part of the CIP/KIP family of cyclin-dependent inhibitors (CKIs) which also includes CDKN1A and CDKN1B.Synonyms: Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57KIP2
Molecular Weight 35 kDa
Gene ID 1028
NCBI Accession NP_000067
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Lee, Reynisdóttir, Massagué: "Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution." in: Genes & development, Vol. 9, Issue 6, pp. 639-49, 1995 (PubMed).

Hatada, Ohashi, Fukushima et al.: "An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome." in: Nature genetics, Vol. 14, Issue 2, pp. 171-3, 1996 (PubMed).

Pateras, Apostolopoulou, Niforou et al.: "p57KIP2: \Kip\"ing the cell under control."" in: Molecular cancer research : MCR, Vol. 7, Issue 12, pp. 1902-19, 2009 (PubMed).

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