SIVA1 antibody (N-Term)

Catalog No. ABIN1450104

This anti-SIVA1 antibody is a Chicken Polyclonal antibody detecting SIVA1 in WB, IF and EIA. Suitable for Human and Mouse.

Quick Overview for SIVA1 antibody (N-Term) (ABIN1450104)

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Reactivity: Human, Mouse

Host: Chicken

Clonality: Polyclonal

Conjugate: This SIVA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-SIVA1 Antibody

Binding Specificity: N-Term

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid synthetic peptide near the amino terminus of human SIVA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SIVA1

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Alternative Name: SIVA1 / SIVA

Background: SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFk-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.Synonyms: Apoptosis regulatory protein Siva, CD27-binding protein, CD27BP

Gene ID: 10572

NCBI Accession: NP_068355

Pathways: Positive Regulation of Endopeptidase Activity