Minichromosome Maintenance Complex Component 6 (MCM6) antibody

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Synonyms CG4039, DmMCM6, DmeMCM6, Dmel\\CG4039, MCM6, McM6, fs(1)K1214, mcm6, MCG40308, Mis5, P105MCM, Mcmd6, mis5, mmcm6, ASP-l1, D1Wsu22e
Mouse (Murine), Rat (Rattus), Human
(75), (18), (11), (10), (2), (2), (1), (1), (1), (1), (1)
(67), (7), (4)
(2), (2), (2), (2), (2), (2)
Western Blotting (WB), Immunohistochemistry (IHC)
(70), (42), (24), (16), (13), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Pubmed 3 references available
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Quantity 200 μg
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Immunogen Recombinant protein of human MCM6
Isotype IgG
Purification Affinity purification  
Alternative Name MCM6 (MCM6 Antibody Abstract)
Background The MCM genes were firstly identified in yeast defective in minichromosome maintenance and have since been shown to have roles in the progression of the cell cycle, and most of them are cell division control genes[PMID: 18096807]. MCM2-7 complex are suggested to be DNA licensing factors which bind to the DNA after mitosis and enable DNA replication before being removed during S phase. Mini-chromosome maintenance 6 (MCM6) is one component of the MCM2-7 complex which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells[PMID: 9305914]. MCM6 single subunit forms homohexamer and contains an ATP-dependent and replication fork stimulated 3 to 5 DNA unwinding activity along with intrinsic DNA-dependent ATPase and ATP-binding activities [PMID:21336027].
Synonyms: Mis5, P105MCM, MCG40308
Gene ID 4175
UniProt Q14566
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins, DNA/RNA
Pathways DNA Damage Repair
Application Notes Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze / thaw cycles
Storage -20 °C/-80 °C
Background publications Tran, Pham, Tuteja et al.: "Inhibition of unwinding and ATPase activities of pea MCM6 DNA helicase by actinomycin and nogalamycin." in: Plant signaling & behavior, Vol. 6, Issue 3, pp. 327-9, 2011 (PubMed).

Groth, Corpet, Cook et al.: "Regulation of replication fork progression through histone supply and demand." in: Science (New York, N.Y.), Vol. 318, Issue 5858, pp. 1928-31, 2007 (PubMed).

Ishimi: "A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex." in: The Journal of biological chemistry, Vol. 272, Issue 39, pp. 24508-13, 1997 (PubMed).

Catalog No. ABIN1514330
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