MCM6 antibody (C-Term)

Catalog No. ABIN6263166

Product Details anti-MCM6 Antibody

Target: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCM6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity: MCM6 Antibody detects endogenous levels of total MCM6.

Predicted Reactivity: Pig,Horse,Sheep,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MCM6, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for MCM6

Target: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Alternative Name: MCM6 (MCM6 Products)

Synonyms: CG4039 antibody, DmMCM6 antibody, DmeMCM6 antibody, Dmel\\CG4039 antibody, MCM6 antibody, McM6 antibody, fs(1)K1214 antibody, mcm6 antibody, MCG40308 antibody, Mis5 antibody, P105MCM antibody, Mcmd6 antibody, mis5 antibody, mmcm6 antibody, ASP-l1 antibody, D1Wsu22e antibody, Minichromosome maintenance 6 antibody, DNA replication licensing factor MCM6 antibody, minichromosome maintenance complex component 6 antibody, minichromosome maintenance complex component 6 L homeolog antibody, DNA replication licensing factor mcm-6 antibody, Mcm6 antibody, TP02_0113 antibody, PVX_114735 antibody, CMU_027970 antibody, MCM6 antibody, mcm6.L antibody, mcm-6 antibody

Background:

Description: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Gene: MCM6

Molecular Weight: 93kDa

Gene ID: 4175

UniProt: Q14566

Pathways: DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA