NFASC antibody (AA 830-1100)

Catalog No. ABIN3017267

This Rabbit Polyclonal antibody specifically detects NFASC in WB. It exhibits reactivity toward Human.

Quick Overview for NFASC antibody (AA 830-1100) (ABIN3017267)

Target: NFASC (Neurofascin (NFASC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFASC antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NFASC Antibody

Binding Specificity: AA 830-1100

Sequence: RFRVRQPNLE TINLEWDHPE HPNGIMIGYT LKYVAFNGTK VGKQIVENFS PNQTKFTVQR TDPVSRYRFT LSARTQVGSG EAVTEESPAP PNEATPTAAP PTLPPTTVGA TGAVSSTDAT AIAATTEATT VPIIPTVAPT TIATTTTVAT TTTTTAAATT TTESPPTTTS GTKIHESAPD EQSIWNVTVL PNSKWANITW KHNFGPGTDF VVEYIDSNHT KKTVPVKAQA QPIQLTDLYP GMTYTLRVYS RDNEGISSTV ITFMTSTAYT N

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 830-1100 of human NFASC (NP_001005388.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NFASC

Target: NFASC (Neurofascin (NFASC))

Alternative Name: NFASC

Background: This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.,NFASC,NF,NRCAML,Neuroscience,NFASC

Molecular Weight: 69 kDa/119 kDa/130-150 kDa

Gene ID: 23114

UniProt: O94856

Pathways: Cell-Cell Junction Organization