CDON antibody (PE)

Catalog No. ABIN1712743

Product Details anti-CDON Antibody (PE)

Target: CDON (Cell Adhesion Molecule-Related/down-Regulated By Oncogenes (CDON))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDON antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CDON

Isotype: IgG

Application Details

Application Notes: FCM(1:20-100)

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4°C

Expiry Date: 12 months

Target Details for CDON

Target: CDON (Cell Adhesion Molecule-Related/down-Regulated By Oncogenes (CDON))

Alternative Name: Cdon (CDON Products)

Background:

Cell adhesion molecule-related/down-regulated by oncogenes (CDO) and BOC (brother of CDO) are members of the immunoglobulin/fibronectin type III repeat family and act as cell surface receptors. CDO is a component of a cell-surface receptor complex which also contains BOC, NEO1, CTNNB1 and cadherins and which acts as a mediator of cell-cell interactions between muscle cells. CDO and BOC are single pass membrane proteins that play a role in myogenic cell differentiation. Together, CDO and BOC participate in a positive feedback loop with MyoD, a myogenic transcription factor. The 1,242 amino acid rat CDO protein has a 24 residue signal sequence, five Ig V-like repeats, a 25 residue membrane-spanning region, three FNIII-like repeats and a cytoplasmic region of 256 amino acids containing a proline-rich stretch. The human protein contains 1,225 amino acid residues and shares significant homology with the domain structures of the rat protein.

Subcellular location: Extracellular

Synonyms: CDO, CDON, Cell adhesion molecule-related/down-regulated by oncogenes, CDON_HUMAN.

Gene ID: 50937

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Embryonic Body Morphogenesis