Minichromosome Maintenance Complex Component 6 (MCM6) (C-Term) antibody

Details for Product No. ABIN183379
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Antigen
Synonyms CG4039, DmMCM6, DmeMCM6, Dmel\\CG4039, MCM6, McM6, fs(1)K1214, mcm6, MCG40308, Mis5, P105MCM, Mcmd6, mis5, mmcm6, ASP-l1, D1Wsu22e
Epitope
C-Term
(11), (8), (7), (4), (1), (1)
Reactivity
Dog (Canine), Mouse (Murine), Rat (Rattus), Cow (Bovine), Human
(39), (11), (8), (3)
Host
Rabbit
(32), (4), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(37), (17), (13), (12), (6), (3), (3), (1), (1), (1)
Pubmed 1 reference available
Quantity 100 µg
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Catalog No. ABIN183379
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Immunogen Synthetic peptide directed towards the C terminal of human MCM6
Sequence RIIEKVIHRL THYDHVLIEL TQAGLKGSTE GSESYEEDPY LVVNPNYLLE
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Human : 100 %, Rabbit : 100 %, Mouse : 90 %, Rat : 90 %
Characteristics This is a rabbit polyclonal antibody against MCM6. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name MCM6
Background The protein encoded by the MCM6 gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.
Molecular Weight 90 kDa
Gene ID 4175
NCBI Accession NP_005906, NM_005915
UniProt Q14566
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins, DNA/RNA
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 821 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Minichromosome Maintenance Complex Component 6 (MCM6) (C-Term) antibody anti-Minichromosome Maintenance Complex Component 6 (MCM6) (C-Term) antibody
anti-Minichromosome Maintenance Complex Component 6 (MCM6) (C-Term) antibody (2) anti-Minichromosome Maintenance Complex Component 6 (MCM6) (C-Term) antibody (Image 2)
Background publications Yabuta, Kajimura, Mayanagi et al.: "Mammalian Mcm2/4/6/7 complex forms a toroidal structure." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 8, Issue 5, pp. 413-21, 2003 (PubMed).

Validation Images
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