HNRPLL antibody (N-Term)

Catalog No. ABIN184075

This Rabbit Polyclonal antibody specifically detects HNRPLL in WB and IHC. It exhibits reactivity toward Human, Cow, Dog, Rabbit and Guinea Pig and has been mentioned in 4+ publications.

Quick Overview for HNRPLL antibody (N-Term) (ABIN184075)

Target: HNRPLL (Heterogeneous Nuclear Ribonucleoprotein L-Like (HNRPLL))

Reactivity: Human, Cow, Dog, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HNRPLL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-HNRPLL Antibody

Binding Specificity: N-Term

Sequence: RLKTEEGEID YSAEEGENRR EATPRGGGDG GGGGRSFSQP EAGGSHHKVS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Rabbit: 100%

Characteristics: This is a rabbit polyclonal antibody against HNRPLL. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HNRPLL

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 542 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HNRPLL antibody (ABIN184075)

Liu, Lei, Yu, Kung, Xie: "Refinement of the spectra of exon usage by combined effects of extracellular stimulus and intracellular factors." in: Biochimica et biophysica acta, Vol. 1839, Issue 7, pp. 537-45, (2014) (PubMed).

Heyd, Lynch: "Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing." in: Molecular cell, Vol. 40, Issue 1, pp. 126-37, (2010) (PubMed).

Yu, Hai, Liu, Fang, Kung, Xie: "The heterogeneous nuclear ribonucleoprotein L is an essential component in the Ca2+/calmodulin-dependent protein kinase IV-regulated alternative splicing through cytidine-adenosine repeats." in: The Journal of biological chemistry, Vol. 284, Issue 3, pp. 1505-13, (2009) (PubMed).

Rajan, Dalgliesh, Bourgeois, Heiner, Emami, Clark, Bindereif, Stevenin, Robson, Leung, Elliott: "Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies." in: BMC cell biology, Vol. 10, pp. 82, (2009) (PubMed).

Target Details for HNRPLL

Target: HNRPLL (Heterogeneous Nuclear Ribonucleoprotein L-Like (HNRPLL))

Alternative Name: HNRPLL

Background: HNRPLL contains 3 RRM (RNA recognition motif) domains and may bind RNA and plays a role in mRNA processing.
Alias Symbols: SRRF, hnRNPLL, HNRPLL
Protein Interaction Partner: HNRNPK, HNRNPLL, RHOXF2, BOLL, THAP1, RBPMS, QKI, UBE2I, MDFI, DAB1, UBC, ATXN1, PAXIP1, BARD1, CNOT3, PCBP1, SUMO2, VHL, PSMA3, HDAC5, DDX39B,
Protein Size: 542

Molecular Weight: 60 kDa

Gene ID: 92906

NCBI Accession: NM_138394, NP_612403

UniProt: Q8WVV9