Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody

Details for Product No. ABIN184575
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Antigen
Synonyms socs1, zgc:91868, jab, cis1, ssi1, tip3, cish1, ssi-1, socs-1, SOCS1, LOC100228306, socs1b, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3, Cish1, Cish7, Socs-1
Epitope
C-Term
(31), (19), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Human
(103), (53), (43), (16), (13), (5), (1), (1), (1)
Host
Goat
(99), (8), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Methode Type Peptide ELISA
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(99), (45), (24), (13), (10), (10), (9), (5), (4), (3), (3)
Pubmed 1 reference available
Quantity 100 μg
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Catalog No. ABIN184575
374.27 $
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Immunogen Peptide with sequence C-VLRDYLSSFPFQI, from the C Terminus of the protein sequence according to NP_003736.1.
Cross-Reactivity Rat (Rattus), Dog (Canine), Cow (Bovine)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name SOCS1
Background Synonyms: SOCS1, JAB, CIS1, SSI1, TIP3, CISH1, Cish1, SSI-1, SOCS-1, suppressor of cytokine signaling 1, JAK binding protein, Tec-interacting protein 3, STAT induced SH3 protein 1, cytokine-inducible SH2 protein 1
Gene ID 8651, 12703
NCBI Accession NP_003736
Research Area Chromatin and Nuclear Signaling, Signaling, Cytokines
Application Notes ELISA: antibody detection limit dilution 1:32000.
Western blot: In transfected HEK293 transiently expressing human SOCS1 bands of approx. 30 kDa and 25 kDa are observed. These bands are not observed in the non-transfected HEK293. A similar pattern is observed in Mouse Spleen lysates. The calculated molecular size is 23.6 kDa according to Human NP_003736.1 and 23.7 kDa according to Mouse NP_034026.1. Recommended concentration: 1-3 µg/mL.
IHC: In paraffin embedded Human Kidney shows strong staining of the Brush Border in PCT. Recommended concentration: 2-3 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody ABIN184575 staining (2 µg/mL) of mouse spleen lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody (2) HEK293 overexpressing SOCS1 and probed with ABIN184575 (mock transfection in lane B).
anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody (3) ABIN184575 (2.5 µg/mL) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
General Starr, Willson, Viney et al.: "A family of cytokine-inducible inhibitors of signalling." in: Nature, Vol. 387, Issue 6636, pp. 917-21, 1997 (PubMed).

Validation Images
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