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SOCS1 Products

(Suppressor of Cytokine Signaling 1 (SOCS1))
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008].

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Featured SOCS1 Categories

SOCS1 Antibodies

High quality antibodies with extensive validation data.

SOCS1 ELISA Kits

Reliable ELISA kits for a wide range of species.

SOCS1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SOCS1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application ELISA, FACS, IF, IHC
Validations
  • (11)
Cat. No. ABIN184575
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application IHC, WB
Validations
  • (7)
Cat. No. ABIN2777164
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application FACS, IF, IHC, ELISA, WB
Validations
  • (9)
Cat. No. ABIN3029042
Quantity 0.4 mL
Datasheet Datasheet

Recommended SOCS1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6959764
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970477
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970479
Quantity 96 tests
Datasheet Datasheet

Recommended SOCS1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (3)
Cat. No. ABIN3131672
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5710396
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Yeast
Validations
  • (1)
Cat. No. ABIN5713854
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our SOCS1 products

Ihedioha, Potter, Chen: "Poor stimulation of bovine dendritic cells by Mycobacterium bovis culture supernatant and surface extract is associated with decreased activation of ERK and NF-κB and higher expression of SOCS1 and 3." in: Innate immunity, Vol. 26, Issue 6, pp. 537-546, (2020) (PubMed).

Li, Chen, Dang, Wang, Shang, Ma, Wang, Zhang, Luo, Li, Zhao: "Corilagin Counteracts IL-13Rα1 Signaling Pathway in Macrophages to Mitigate Schistosome Egg-Induced Hepatic Fibrosis." in: Frontiers in cellular and infection microbiology, Vol. 7, pp. 443, (2018) (PubMed).

Yang, Tian, Zhang, Xu, Yang, Yu, Li, Li, Li, Li: "Role of the JAK2/STAT3 signaling pathway in the pathogenesis of type 2 diabetes mellitus with macrovascular complications." in: Oncotarget, Vol. 8, Issue 57, pp. 96958-96969, (2017) (PubMed).

Du, Ma, Zhu, Li, Wang, Li, Chen, Shang, Zhang, Zhao: "Mechanism of Corilagin interference with IL-13/STAT6 signaling pathways in hepatic alternative activation macrophages in schistosomiasis-induced liver fibrosis in mouse model." in: European journal of pharmacology, Vol. 793, pp. 119-126, (2017) (PubMed).

Ma, Xue, Wang, Shu, Zhang: "MicroRNA-155 may be involved in the pathogenesis of atopic dermatitis by modulating the differentiation and function of T helper type 17 (Th17) cells." in: Clinical and experimental immunology, Vol. 181, Issue 1, pp. 142-9, (2015) (PubMed).

Nazmi, Mukherjee, Kundu, Dutta, Mahadevan, Shankar, Basu: "TLR7 is a key regulator of innate immunity against Japanese encephalitis virus infection." in: Neurobiology of disease, Vol. 69, pp. 235-47, (2014) (PubMed).

Mathieu, Miles, Ahmad, Buczek, Pockley, Rees, Regad: "The helicase HAGE prevents interferon-α-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1." in: Cell death & disease, Vol. 5, pp. e1061, (2014) (PubMed).

Bunda, Kommaraju, Heir, Ohh: "SOCS-1 mediates ubiquitylation and degradation of GM-CSF receptor." in: PLoS ONE, Vol. 8, Issue 9, pp. e76370, (2013) (PubMed).

Pellegrini, Calzascia, Toe, Preston, Lin, Elford, Shahinian, Lang, Lang, Morre, Assouline, Lahl, Sparwasser, Tedder, Paik, DePinho, Basta, Ohashi, Mak: "IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology." in: Cell, Vol. 144, Issue 4, pp. 601-13, (2011) (PubMed).

Russell, Sufan, Zhou, Heir, Bunda, Sybingco, Greer, Roche, Heathcote, Chow, Boba, Richmond, Hickey, Barber, Cheresh, Simon, Irwin, Kim, Ohh: "Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia." in: Nature medicine, Vol. 17, Issue 7, pp. 845-53, (2011) (PubMed).

Synonyms and alternative names related to SOCS1

suppressor of cytokine signaling 1a (socs1a), suppressor of cytokine signaling 1 (socs1), suppressor of cytokine signaling 1 (SOCS1), suppressor of cytokine signaling 1 L homeolog (socs1.L), suppressor of cytokine signaling 1 (Socs1), cis1, CIS1, cish1, CISH1, Cish1, Cish7, jab, JAB, LOC100228306, socs-1, SOCS-1, Socs-1, socs1, SOCS1, socs1b, ssi-1, SSI-1, ssi1, SSI1, tip3, TIP3, zgc:91868

Protein level used designations for SOCS1

  • suppressor of cytokine signaling 1
  • suppressor of cytokine signalling
  • suppressor of cytokine signaling 1b
  • suppressor of cytokine signaling 1-like protein
  • JAK binding protein
  • JAK-binding protein
  • STAT induced SH3 protein 1
  • STAT-induced STAT inhibitor 1
  • TIP-3
  • Tec-interacting protein 3
  • cytokine-inducible SH2 protein 1
  • JAK2-binding protein
  • cytokine inducible SH2-containing protein 1
  • cytokine inducible SH2-containing protein 7
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