NOXA antibody (Phorbol-12-Myristate-13-Acetate-Induced Protein 1)

Details for Product anti-PMAIP1 Antibody No. ABIN187551, Supplier: Log in to see
Antigen
  • TN3
  • PMAIP1
  • zgc:162379
  • APR
  • NOXA
  • Noxa
  • phorbol-12-myristate-13-acetate-induced protein 1
  • PMAIP1
  • pmaip1
  • Pmaip1
Alternatives
anti-Human NOXA antibody for ELISA
Reactivity
Human
96
77
46
1
Host
Rat
44
40
28
16
Clonality (Clone)
Monoclonal ()
Conjugate
This NOXA antibody is un-conjugated
6
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
1
1
Application
Western Blotting (WB)
121
36
35
24
22
21
2
1
1
Options
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Immunogen Recombinant human Noxa.
Clone 114C307
Isotype IgG1
Specificity Recognizes human Noxa. Detects a band of approximately 11 kDa by Western blot. Species Reactivity: Human. Others not tested.
Alternative Name NOXA (PMAIP1 Antibody Abstract)
Pathways p53 Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
Application Notes Western blot: Use at 1-2 µg/mL. Immunocytochemistry The optimal dilution for a specific application should be determined by the researcher.
Restrictions For Research Use only
Format Liquid
Buffer 100 µg of liquid Protein G affinity-purified monoclonal antibody at 0.5 mg/mL in PBS containing protein stabilizer and 0.05% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
 image for anti-NOXA antibody (Phorbol-12-Myristate-13-Acetate-Induced Protein 1) (ABIN187551) anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) antibody
Background publications Hauck, Chao, Litz, Krystal: "Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737." in: Molecular cancer therapeutics, Vol. 8, Issue 4, pp. 883-92, 2009 (PubMed).

Kutuk, Arisan, Tezil, Shoshan, Basaga: "Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation." in: Carcinogenesis, 2009 (PubMed).

Ploner, Rainer, Lobenwein, Geley, Kofler: "Repression of the BH3-only molecule PMAIP1/Noxa impairs glucocorticoid sensitivity of acute lymphoblastic leukemia cells." in: Apoptosis : an international journal on programmed cell death, Vol. 14, Issue 6, pp. 821-8, 2009 (PubMed).

Stankiewicz, Livingstone, Mohseni, Mosser: "Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70." in: Cell death and differentiation, Vol. 16, Issue 4, pp. 638-47, 2009 (PubMed).

Forest, Hadjeres, Bertrand, Jean-Franucois: "Optimisation and molecular signalling of apoptosis in sequential cryotherapy and chemotherapy combination in human A549 lung cancer xenografts in SCID mice." in: British journal of cancer, Vol. 100, Issue 12, pp. 1896-902, 2009 (PubMed).

Kojima, Shimanuki, Shikami, Samudio, Ruvolo, Corn, Hanaoka, Konopleva, Andreeff, Nakakuma: "The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 22, Issue 9, pp. 1728-36, 2008 (PubMed).

Kurata, Yanagisawa, Ohira, Kitagawa, Nakagawara, Kamijo: "Stress via p53 pathway causes apoptosis by mitochondrial Noxa upregulation in doxorubicin-treated neuroblastoma cells." in: Oncogene, Vol. 27, Issue 6, pp. 741-54, 2008 (PubMed).

Anderton, Yee, Smith, Crook, White, Allday: "Two Epstein-Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma." in: Oncogene, Vol. 27, Issue 4, pp. 421-33, 2008 (PubMed).

Sasaki, Negishi, Idogawa, Suzuki, Mita, Toyota, Shinomura, Imai, Tokino: "Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models." in: Molecular cancer therapeutics, Vol. 7, Issue 4, pp. 779-87, 2008 (PubMed).

Braun, Zhang, Savelyeva, Wolff, Moll, Schepeler, uorntoft, Andersen, Dobbelstein: "p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest." in: Cancer research, Vol. 68, Issue 24, pp. 10094-104, 2008 (PubMed).

Flanagan, Letai: "BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2." in: Cell death and differentiation, Vol. 15, Issue 3, pp. 580-8, 2008 (PubMed).

Nefedova, Sullivan, Bolick, Dalton, Gabrilovich: "Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy." in: Blood, Vol. 111, Issue 4, pp. 2220-9, 2008 (PubMed).

van Gent, Kater, Otto, Jaspers, Borghans, Vrisekoop, Ackermans, Ruiter, Wittebol, Eldering, van Oers, Tesselaar, Kersten, Miedema: "In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow." in: Cancer research, Vol. 68, Issue 24, pp. 10137-44, 2008 (PubMed).

Hallaert, Jaspers, van Noesel, van Oers, Kater, Eldering: "c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches." in: Blood, Vol. 112, Issue 13, pp. 5141-9, 2008 (PubMed).

Deng, Shimamura, Perera, Carlson, Cai, Shapiro, Wong, Letai: "Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion." in: Cancer research, Vol. 67, Issue 24, pp. 11867-75, 2007 (PubMed).

Puerez-Galuan, Rouue, Villamor, Campo, Colomer: "The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak." in: Blood, Vol. 109, Issue 10, pp. 4441-9, 2007 (PubMed).

Smit, Hallaert, Spijker, de Goeij, Jaspers, Kater, van Oers, van Noesel, Eldering: "Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity." in: Blood, Vol. 109, Issue 4, pp. 1660-8, 2007 (PubMed).

Kojima, Konopleva, Samudio, Ruvolo, Andreeff: "Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells." in: Cancer research, Vol. 67, Issue 7, pp. 3210-9, 2007 (PubMed).

Guomez-Benito, Balsas, Carvajal-Vergara, Pandiella, Anel, Marzo, Naval: "Mechanism of apoptosis induced by IFN-alpha in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin." in: Cellular signalling, Vol. 19, Issue 4, pp. 844-54, 2007 (PubMed).

Poulaki, Mitsiades, Kotoula, Negri, McMillin, Miller, Mitsiades: "The proteasome inhibitor bortezomib induces apoptosis in human retinoblastoma cell lines in vitro." in: Investigative ophthalmology & visual science, Vol. 48, Issue 10, pp. 4706-19, 2007 (PubMed).