NOXA antibody (AA 1-54)

Catalog No. ABIN7193484

The Mouse Monoclonal anti-NOXA antibody (Clone 1A2D3) (ABIN7193484) specifically detects NOXA in ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for NOXA antibody (AA 1-54) (ABIN7193484)

Target: NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NOXA antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 1A2D3

Product Details anti-NOXA Antibody

Binding Specificity: AA 1-54

Purpose: PMAIP1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PMAIP1 (AA: 1-54) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for NOXA

Target: NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))

Alternative Name: PMAIP1

Background:

The protein encoded by this gene promotes activation of caspases and apoptosis, Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

Molecular Weight: 6 kDa

Gene ID: 5366

UniProt: Q13794

Pathways: p53 Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus