NOXA Products
(Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))
Categories
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
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Featured NOXA Categories
NOXA Antibodies
High quality antibodies with extensive validation data.
NOXA ELISA Kits
Reliable ELISA kits for a wide range of species.
NOXA Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NOXA Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (5)
Cat. No.
ABIN6145810
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (4)
Cat. No.
ABIN7193484
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7163088
Quantity
100 μg
Datasheet
Datasheet
Recommended NOXA ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969250
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969249
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6220151
Quantity
96 tests
Datasheet
Datasheet
Recommended NOXA Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315507
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3089046
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3130350
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our NOXA products
: "Genome-scale CRISPR screening for potential targets of ginsenoside compound K." in: Cell death & disease, Vol. 11, Issue 1, pp. 39, (2021) (PubMed).: "HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma." in: International journal of cancer, Vol. 142, Issue 9, pp. 1926-1937, (2019) (PubMed).
: "Targeting prosurvival BCL2 signaling through Akt blockade sensitizes castration-resistant prostate cancer cells to enzalutamide." in: The Prostate, Vol. 79, Issue 11, pp. 1347-1359, (2019) (PubMed).
: "Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia." in: Cancer research, Vol. 78, Issue 20, pp. 5793-5807, (2018) (PubMed).
: "Mannose impairs tumour growth and enhances chemotherapy." in: Nature, Vol. 563, Issue 7733, pp. 719-723, (2018) (PubMed).
: "Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins." in: Oncogene, Vol. 36, Issue 35, pp. 4953-4962, (2017) (PubMed).
: "Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice." in: Cell death & disease, Vol. 8, Issue 1, pp. e2556, (2017) (PubMed).
: "Bax/Bak activation in the absence of Bid, Bim, Puma, and p53." in: Cell death & disease, Vol. 7, pp. e2266, (2016) (PubMed).
: "p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death." in: Oncogene, (2015) (PubMed).
: "Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner." in: Gut, Vol. 64, Issue 7, pp. 1040-8, (2015) (PubMed).
Synonyms and alternative names related to NOXA
phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1), phorbol-12-myristate-13-acetate-induced protein 1 (pmaip1), phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1), APR, NOXA, Noxa, PMAIP1, TN3, zgc:162379Protein level used designations for NOXA
- phorbol-12-myristate-13-acetate-induced protein 1
- Noxa
- PMA-induced protein 1
- adult T cell leukemia-derived PMA-responsive
- immediate-early-response protein APR
- protein Noxa
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