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Details for Product No. ABIN187551

Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) antibody

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Antigen
Synonyms APR, NOXA, Noxa, TN3, PMAIP1, zgc:162379
Reactivity
»Alternatives Human
Host
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 20 references available
Catalog no. ABIN187551
Quantity 100 µg
Price
566.13 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 11 to 16 Business Days
Immunogen Recombinant human Noxa.
Clone 114C307
Isotype IgG1
Specificity Recognizes human Noxa. Detects a band of approximately 11 kDa by Western blot. Species Reactivity: Human. Others not tested.
Alternative Name NOXA
Application Notes Western blot: Use at 1-2 µg/mL. Immunocytochemistry The optimal dilution for a specific application should be determined by the researcher.
Restrictions For Research Use only
Format Liquid
Buffer 100 µg of liquid Protein G affinity-purified monoclonal antibody at 0.5 mg/mL in PBS containing protein stabilizer and 0.05% sodium azide.
Preservative Sodium azide
Storage 4 °C
Smit, Hallaert, Spijker et al.: "Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity." in: Blood, Vol. 109, Issue 4, pp. 1660-8, 2007 (PubMed).

Guomez-Benito, Balsas, Carvajal-Vergara et al.: "Mechanism of apoptosis induced by IFN-alpha in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin." in: Cellular signalling, Vol. 19, Issue 4, pp. 844-54, 2007 (PubMed).

Puerez-Galuan, Rouue, Villamor et al.: "The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak." in: Blood, Vol. 109, Issue 10, pp. 4441-9, 2007 (PubMed).

Kojima, Konopleva, Samudio et al.: "Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells." in: Cancer research, Vol. 67, Issue 7, pp. 3210-9, 2007 (PubMed).

Kurata, Yanagisawa, Ohira et al.: "Stress via p53 pathway causes apoptosis by mitochondrial Noxa upregulation in doxorubicin-treated neuroblastoma cells." in: Oncogene, Vol. 27, Issue 6, pp. 741-54, 2008 (PubMed).

Anderton, Yee, Smith et al.: "Two Epstein-Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma." in: Oncogene, Vol. 27, Issue 4, pp. 421-33, 2008 (PubMed).

Poulaki, Mitsiades, Kotoula et al.: "The proteasome inhibitor bortezomib induces apoptosis in human retinoblastoma cell lines in vitro." in: Investigative ophthalmology & visual science, Vol. 48, Issue 10, pp. 4706-19, 2007 (PubMed).

Nefedova, Sullivan, Bolick et al.: "Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy." in: Blood, Vol. 111, Issue 4, pp. 2220-9, 2008 (PubMed).

Flanagan, Letai: "BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2." in: Cell death and differentiation, Vol. 15, Issue 3, pp. 580-8, 2008 (PubMed).

Deng, Shimamura, Perera et al.: "Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion." in: Cancer research, Vol. 67, Issue 24, pp. 11867-75, 2007 (PubMed).

Sasaki, Negishi, Idogawa et al.: "Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models." in: Molecular cancer therapeutics, Vol. 7, Issue 4, pp. 779-87, 2008 (PubMed).

Kojima, Shimanuki, Shikami et al.: "The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 22, Issue 9, pp. 1728-36, 2008 (PubMed).

Hallaert, Jaspers, van Noesel et al.: "c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches." in: Blood, Vol. 112, Issue 13, pp. 5141-9, 2008 (PubMed).

Braun, Zhang, Savelyeva et al.: "p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest." in: Cancer research, Vol. 68, Issue 24, pp. 10094-104, 2008 (PubMed).

van Gent, Kater, Otto et al.: "In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow." in: Cancer research, Vol. 68, Issue 24, pp. 10137-44, 2008 (PubMed).

Stankiewicz, Livingstone, Mohseni et al.: "Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70." in: Cell death and differentiation, Vol. 16, Issue 4, pp. 638-47, 2009 (PubMed).

Hauck, Chao, Litz et al.: "Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737." in: Molecular cancer therapeutics, Vol. 8, Issue 4, pp. 883-92, 2009 (PubMed).

Ploner, Rainer, Lobenwein et al.: "Repression of the BH3-only molecule PMAIP1/Noxa impairs glucocorticoid sensitivity of acute lymphoblastic leukemia cells." in: Apoptosis : an international journal on programmed cell death, Vol. 14, Issue 6, pp. 821-8, 2009 (PubMed).

Forest, Hadjeres, Bertrand et al.: "Optimisation and molecular signalling of apoptosis in sequential cryotherapy and chemotherapy combination in human A549 lung cancer xenografts in SCID mice." in: British journal of cancer, Vol. 100, Issue 12, pp. 1896-902, 2009 (PubMed).

Kutuk, Arisan, Tezil et al.: "Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation." in: Carcinogenesis, 2009 (PubMed).

Alternatives for antigen "Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1)", type "Antibodies"
Hosts (46), (12), (3)
Reactivities (49), (40), (27), (11), (1)
Applications (47), (17), (17), (9), (7), (5), (4), (2), (1), (1)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (3), (3), (2), (1), (1)
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