ATP1A3 antibody (AA 805-833)

Catalog No. ABIN1881087

Product Details anti-ATP1A3 Antibody

Target: ATP1A3 (ATPase, Na+/K+ Transporting, alpha 3 Polypeptide (ATP1A3))

Binding Specificity: AA 805-833

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP1A3 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: C, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ATP1A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 805-833 amino acids from the Central region of human ATP1A3.

Clone: RB42176

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ATP1A3 antibody (ABIN1881087)

Einholm, Toustrup-Jensen, Holm, Andersen, Vilsen: "The rapid-onset dystonia parkinsonism mutation D923N of the Na+, K+-ATPase alpha3 isoform disrupts Na+ interaction at the third Na+ site." in: The Journal of biological chemistry, Vol. 285, Issue 34, pp. 26245-54, (2010) (PubMed).

Floyd, Wray, Quenby, Martín-Vasallo, Mobasheri: "Expression and distribution of Na, K-ATPase isoforms in the human uterus." in: Reproductive sciences (Thousand Oaks, Calif.), Vol. 17, Issue 4, pp. 366-76, (2010) (PubMed).

Goldstein, Lerer, Laiba, Mallet, Mujaheed, Laurent, Rosen, Ebstein, Lichtstein: "Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders." in: Biological psychiatry, Vol. 65, Issue 11, pp. 985-91, (2009) (PubMed).

Target Details for ATP1A3

Target: ATP1A3 (ATPase, Na+/K+ Transporting, alpha 3 Polypeptide (ATP1A3))

Alternative Name: ATP1A3 (ATP1A3 Products)

Background: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.

Molecular Weight: 111749

NCBI Accession: NP_001243142, NP_001243143, NP_689509

UniProt: P13637

Pathways: Thyroid Hormone Synthesis, Proton Transport, Ribonucleoside Biosynthetic Process