FBXW4 antibody (C-Term)

Catalog No. ABIN1881340

This Rabbit Polyclonal antibody specifically detects FBXW4 in WB. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for FBXW4 antibody (C-Term) (ABIN1881340)

Target: FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW4 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB42400

Product Details anti-FBXW4 Antibody

Binding Specificity: AA 341-370, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FBXW4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human FBXW4.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-FBXW4 antibody (ABIN1881340)

Everman, Morgan, Lyle, Laughridge, Bamshad, Clarkson, Colby, Gurrieri, Innes, Roberson, Schrander-Stumpel, van Bokhoven, Antonarakis, Schwartz: "Frequency of genomic rearrangements involving the SHFM3 locus at chromosome 10q24 in syndromic and non-syndromic split-hand/foot malformation." in: American journal of medical genetics. Part A, Vol. 140, Issue 13, pp. 1375-83, (2006) (PubMed).

Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: "The DNA sequence and comparative analysis of human chromosome 10. ..." in: Nature, Vol. 429, Issue 6990, pp. 375-81, (2004) (PubMed).

Target Details for FBXW4

Target: FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))

Alternative Name: FBXW4

Background: This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds, disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.

Molecular Weight: 46337

NCBI Accession: NP_071322

UniProt: P57775