GAB2 antibody (N-Term)

Catalog No. ABIN1881358

This Rabbit Polyclonal antibody specifically detects GAB2 in WB and FACS. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for GAB2 antibody (N-Term) (ABIN1881358)

Target: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAB2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB21209

Product Details anti-GAB2 Antibody

Binding Specificity: AA 3-30, N-Term

Predicted Reactivity: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GAB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-30 amino acids from the N-terminal region of human GAB2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-GAB2 antibody (ABIN1881358)

Dunn, Cheung, Agarwalla, Thomas, Zektser, Karst, Boehm, Weir, Berlin, Zou, Getz, Liu, Hirsch, Vazquez, Root, Beroukhim, Drapkin, Hahn: "In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 3, pp. 1102-7, (2014) (PubMed).

Yamasaki, Nishida, Hibi, Sakuma, Shiina, Takeuchi, Ohnishi, Hirano, Saito: "Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules." in: The Journal of biological chemistry, Vol. 276, Issue 48, pp. 45175-83, (2001) (PubMed).

Target Details for GAB2

Target: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Alternative Name: GAB2

Background: GAB2 is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor.

Molecular Weight: 74458

NCBI Accession: NP_036428, NP_536739

UniProt: Q9UQC2

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, BCR Signaling, Warburg Effect