CDK11 antibody

Catalog No. ABIN1944862

This Rabbit Polyclonal antibody specifically detects CDK11 in WB. It exhibits reactivity toward Human and Mouse and has been mentioned in 5+ publications.

Quick Overview for CDK11 antibody (ABIN1944862)

Target: CDK11 (CDK11B) (Cyclin-Dependent Kinase 11B (CDK11B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK11 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CDK11 Antibody

Isotype: IgG

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C,-20 °C

References for anti-CDK11 antibody (ABIN1944862)

Gururajan, Lahti, Grenet, Easton, Gruber, Ambros, Kidd: "Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2." in: Genome research, Vol. 8, Issue 9, pp. 929-39, (1998) (PubMed).

Xiang, Lahti, Grenet, Easton, Kidd: "Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms." in: The Journal of biological chemistry, Vol. 269, Issue 22, pp. 15786-94, (1994) (PubMed).

Eipers, Lahti, Kidd: "Structure and expression of the human p58clk-1 protein kinase chromosomal gene." in: Genomics, Vol. 13, Issue 3, pp. 613-21, (1992) (PubMed).

Lake, de la Cruz, Ferreira, Morel, Simpson: "Evolution of parasitism: kinetoplastid protozoan history reconstructed from mitochondrial rRNA gene sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 6, pp. 2612, (1991) (PubMed).

Bunnell, Heath, Adams, Lahti, Kidd: "Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 19, pp. 7467-71, (1990) (PubMed).

Target Details for CDK11

Target: CDK11 (CDK11B) (Cyclin-Dependent Kinase 11B (CDK11B))

Alternative Name: CDC2L1

Background: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.

Molecular Weight: 92707 Da

Gene ID: 984

UniProt: P21127

Pathways: Regulation of Lipid Metabolism by PPARalpha, M Phase