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Details for Product No. ABIN317572

TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody

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Antigen
Synonyms ALS10, TDP-43, Tdp43, C85084, 1190002A23Rik, wu:fb77f02, wu:fc52g10, TARDBP, TDP43, DKFZp459I2127, tardbp
Epitope
»Alternatives AA 1-260, N-Term
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 2 references available
Catalog no. ABIN317572
Quantity 0.1 mL
Price
401.50 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant Human TARDBP (1-260 aa) purified from E. coli.
Clone K1B8
Isotype IgG1
Characteristics Synonyms: TDP43, TDP-43, TAR DNA-binding protein 43
Purification Protein-G Affinity Chromatography
Alternative Name TARDBP
Background TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBPwas identified as the disease accumulating protein in patients with frontotemporal lobardegeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis(ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNAsequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as atranscriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulatesalternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.
UniProt Q13148
Research Area Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA, Hormones, Cytokines
Application Notes ELISA. Western blot (1/1,000-1/2,000). Immunohistochemistry on Paraffin Sections (1/50-1/100). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4 0.09% Sodium Azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Kabashi, Valdmanis, Dion et al.: "TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis." in: Nature genetics, Vol. 40, Issue 5, pp. 572-4, 2008 (PubMed).

Rutherford, Zhang, Baker et al.: "Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis." in: PLoS genetics, Vol. 4, Issue 9, pp. e1000193, 2008 (PubMed).

Alternatives for antigen "TAR DNA Binding Protein (TARDBP)", type "Antibodies"
Hosts (89), (23), (6), (1)
Reactivities (115), (68), (48), (34), (19), (19), (17), (17), (5), (3), (1)
Applications (104), (49), (21), (21), (20), (19), (10), (3), (3), (1), (1)
Conjugates (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (13), (8), (7), (7), (6), (3), (3), (2), (1), (1), (1)
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