TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody

Details for Product No. ABIN317572
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms TARDBP, TDP43, DKFZp459I2127, tardbp, ALS10, TDP-43, 1190002A23Rik, C85084, Tdp43, wu:fb77f02, wu:fc52g10
Epitope
AA 1-260, N-Term
(21), (21), (13), (13), (7), (7), (7), (4), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(119), (59), (50), (23), (16), (8), (7), (6), (5), (3), (1), (1)
Host
Mouse
(92), (28), (5), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(108), (48), (30), (24), (23), (23), (10), (6), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN317572
412.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Recombinant Human TARDBP (1-260 aa) purified from E. coli.
Clone K1B8
Isotype IgG1
Characteristics Synonyms: TDP43, TDP-43, TAR DNA-binding protein 43
Purification Protein-G Affinity Chromatography
Alternative Name TARDBP
Background TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBPwas identified as the disease accumulating protein in patients with frontotemporal lobardegeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis(ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNAsequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as atranscriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulatesalternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.
UniProt Q13148
Research Area Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA, Hormones, Cytokines
Application Notes ELISA. Western blot (1/1,000-1/2,000). Immunohistochemistry on Paraffin Sections (1/50-1/100). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4 0.09% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody
anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody (2) anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody (Image 2)
anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody (3) anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody (Image 3)
Background publications Kabashi, Valdmanis, Dion et al.: "TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis." in: Nature genetics, Vol. 40, Issue 5, pp. 572-4, 2008 (PubMed).

Rutherford, Zhang, Baker et al.: "Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis." in: PLoS genetics, Vol. 4, Issue 9, pp. e1000193, 2008 (PubMed).

Validation Images
Did you look for something else?
back to top