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Aurora Kinase A (AURKA) (pThr288) antibody

Details for Product No. ABIN319281
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Antigen
Synonyms
AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, AIRK1, AU019385, AW539821, Ark1, Aurora-A, Ayk1, IAK, IAK1, Stk6, ARK-1, Eg2, aik, ark1, aur-a, aura, aurka-a, aurora2, btak, stk15, stk6, s ... show more
AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, AIRK1, AU019385, AW539821, Ark1, Aurora-A, Ayk1, IAK, IAK1, Stk6, ARK-1, Eg2, aik, ark1, aur-a, aura, aurka-a, aurora2, btak, stk15, stk6, stk7, 87A7-9/2, Aur-A, AurA, CG3068, Dmel\\CG3068, aur-A, aurA, ck10, ck[10], l(3)87Ac, l(3)ck10, pEg2, wu:fb37c10, wu:fc02c02, zgc:100912, AURKA, aurka show less
Epitope
pThr288
(29), (25), (13), (7), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(168), (54), (45), (27), (26), (13), (12)
Host
Rabbit
(125), (44), (12), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(135), (74), (42), (38), (37), (26), (20), (18), (9), (5), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN319281
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Aurora A around the phosphorylation site of Threonine 288 (R-T-TP-L-M).
Specificity Aurora A (phospho-Thr288) Antibody detects endogenous levels of Aurora A only when phosphorylated at Threonine 288.
Purification Immunoaffinity Chromatography: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Aurora kinase A
Background Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.
Alternate names: AIK1, ARK1, AURA, AURKA, AURORA2, Aurora/IPL1-related kinase 1, BTAK, Breast tumor- amplified kinase, STK15, STK6, Serine/threonine kinase 15, Serine/threonine-protein kinase 6
Gene ID 6790
NCBI Accession NP_003591.2
UniProt O14965
Application Notes Immunohistochemistry (1/50-1/100). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20°C.
Expiry Date 12 months
Supplier Images
anti-Aurora Kinase A (AURKA) (pThr288) antibody anti-Aurora Kinase A (AURKA) (pThr288) antibody
Background publications Bischoff, Anderson, Zhu et al.: "A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers." in: The EMBO journal, Vol. 17, Issue 11, pp. 3052-65, 1998 (PubMed).

Ellis: "The war of the sex chromosomes." in: Nature genetics, Vol. 20, Issue 1, pp. 9-10, 1998 (PubMed).

Walter, Seghezzi, Korver et al.: "The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation." in: Oncogene, Vol. 19, Issue 42, pp. 4906-16, 2000 (PubMed).

Hauf, Cole, LaTerra et al.: "The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint." in: The Journal of cell biology, Vol. 161, Issue 2, pp. 281-94, 2003 (PubMed).

Hosts (125), (44), (12), (1)
Reactivities (168), (54), (45), (27), (26), (13), (12)
Applications (135), (74), (42), (38), (37), (26), (20), (18), (9), (5), (1), (1)
Conjugates (8), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (29), (25), (13), (7), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN319281
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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