anti-Aurora A antibody (Aurora Kinase A) (pThr288)

Details for Product anti-AURKA Antibody No. ABIN319281
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Antigen
Synonyms
87A7-9/2, Aur-A, AurA, CG3068, Dmel\\CG3068, aur-A, aurA, ck10, ck[10], l(3)87Ac, l(3)ck10, Aurora-A, Eg2, aik, ark1, aur-a, aura, aurora2, btak, pEg2, stk15, stk6, stk7, wu:fb37c10, wu:fc02c02, zgc:1 ... show more
87A7-9/2, Aur-A, AurA, CG3068, Dmel\\CG3068, aur-A, aurA, ck10, ck[10], l(3)87Ac, l(3)ck10, Aurora-A, Eg2, aik, ark1, aur-a, aura, aurora2, btak, pEg2, stk15, stk6, stk7, wu:fb37c10, wu:fc02c02, zgc:100912, AURKA, aurka, AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, AIRK1, AU019385, AW539821, Ark1, Ayk1, IAK, IAK1, Stk6, ARK-1, aurka-a show less
Epitope
pThr288
(44), (35), (26), (15), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(209), (65), (39), (10), (5), (3), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(157), (57), (21)
Clonality
Polyclonal
Conjugate
This Aurora A antibody is un-conjugated
(12), (6), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(179), (80), (71), (47), (35), (31), (17), (12), (10), (6), (5), (4), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Aurora A around the phosphorylation site of Threonine 288 (R-T-TP-L-M).
Specificity Aurora A (phospho-Thr288) Antibody AP08036PU detects endogenous levels of Aurora A only when phosphorylated at Threonine 288.
Purification Immunoaffinity Chromatography: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Aurora Kinase A (AURKA Antibody Abstract)
Background Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.Synonyms: AIK1, ARK1, AURA, AURKA, AURORA2, Aurora/IPL1-related kinase 1, BTAK, Breast tumor-amplified kinase, STK15, STK6, Serine/threonine kinase 15, Serine/threonine-protein kinase 6
Gene ID 6790
NCBI Accession NP_003591
UniProt O14965
Application Notes Immunohistochemistry (1/50-1/100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20 °C.
Supplier Images
anti-Aurora Kinase A (AURKA) (pThr288) antibody anti-Aurora Kinase A (AURKA) (pThr288) antibody
Background publications Hauf, Cole, LaTerra et al.: "The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint." in: The Journal of cell biology, Vol. 161, Issue 2, pp. 281-94, 2003 (PubMed).

Walter, Seghezzi, Korver et al.: "The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation." in: Oncogene, Vol. 19, Issue 42, pp. 4906-16, 2000 (PubMed).

Ellis: "The war of the sex chromosomes." in: Nature genetics, Vol. 20, Issue 1, pp. 9-10, 1998 (PubMed).

Bischoff, Anderson, Zhu et al.: "A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers." in: The EMBO journal, Vol. 17, Issue 11, pp. 3052-65, 1998 (PubMed).

Validation Images
Catalog No. ABIN319281
357.50 $
Plus shipping costs $45.00
Quantity
Price
0.1 mL
357.50 $

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