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Dynactin 1 antibody (AA 120-170)

DCTN1 Reactivity: Human WB, IHC Host: Sheep Polyclonal unconjugated

Catalog No. ABIN350282

Datasheet as PDF

Target See all Dynactin 1 (DCTN1) Antibodies

Dynactin 1 (DCTN1)
Binding Specificity
15

4

4

2

2

2

2

1

1

1

1

1

1

1
AA 120-170
Reactivity
52

20

14

5

4

3

2

2

2

1

1

1

1
Human
Host
38

12

2

1
Sheep
Clonality
41

12
Polyclonal
Conjugate
32

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This Dynactin 1 antibody is un-conjugated
Application
44

16

13

13

11

7

6

5

5

3

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

Specificity

Specific for DCTN1.

Cross-Reactivity

Human, Mouse, Rat

Cross-Reactivity (Details)

Other species not yet tested.

Purification

IgG

Immunogen

A synthetic peptide from AA 120-170 of human DCTN1 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and moue.

Isotype

IgG

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DCTN1 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated

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DCTN1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

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DCTN1 Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated

anti-Dynactin 1 (DCTN1) (N-Term) antibody
DCTN1 Reactivity: Human WB, IP Host: Mouse Monoclonal unconjugated

anti-Dynactin 1 (DCTN1) (AA 1-198) antibody
DCTN1 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 2E4-1C2 unconjugated

anti-Dynactin 1 (DCTN1) antibody
DCTN1 Reactivity: Human, Mouse, Rat IF Host: Rabbit Polyclonal unconjugated

anti-Dynactin 1 (DCTN1) (AA 1216-1278) antibody
DCTN1 Reactivity: Human WB, IHC, ICC, IHC (p) Host: Rabbit Polyclonal unconjugated

anti-Dynactin 1 (DCTN1) (C-Term) antibody
DCTN1 Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Rabbit, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated

Application Notes

IHC, WB. Use at a concentration of 10-50 μg,ml. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Restrictions

For Research Use only
Format

Lyophilized

Reconstitution

Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice

Avoid freeze and thaw cycles.

Storage

4 °C/-20 °C

Storage Comment

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months
Target

Dynactin 1 (DCTN1)

Alternative Name

DCTN1 (DCTN1 Products)

Background

FUNCTION: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles. SUBUNIT: Large macromolecular complex of at least 10 components, p150(glued) binds directly to microtubules and to cytoplasmic dynein. Interacts with the C-terminus of MAPRE1, MAPRE2 and MAPRE3. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. TISSUE SPECIFICITY: Brain. DISEASE: Defects in DCTN1 are the cause of progressive lower motor neuron disease. PLMND is a progressive dominant disease that has no sensory symptoms.,Signal Transduction,DAP-150, DP-150, p150-glued,p135, Dynactin subunit 1, 150 kDa dynein-associated polypeptide

UniProt

Q14203

Pathways

M Phase, ER-Nucleus Signaling