Endothelin Receptor Type B (EDNRB) (C-Term) antibody

Antigen: Endothelin Receptor Type B (EDNRB)

Synonyms: ETB, ETBR, ETRB, HSCR, ABCDS, HSCR2, s, ETb, ET-B, ET>B<, ETR-b, Sox10m1, AU022549, Etb, Ednra, MGC142327, EDNRB, etb, etrb, hscr, abcds, hscr2, MGC145633, ednrb, MGC147408

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350307

Additional Information

Alternative name: Endothelin B receptor (EDNRB)

UniProt: P24530

Immunogen: A synthetic peptide from the c-terminal of human Endothelin B receptor (EDNRB) conjugated to an immunogenic carrier protein was used as the immunogen. The peptide is homologous in rat and mouse.

Format: Lyophilized

Isotype: IgG

Description: FUNCTION: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Subcellular location: Cell membrane; Multi-pass membrane protein. Tissue specificity: Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. Also known as: Endothelin receptor non-selective type, EDNRB, ETRB.

Specificity: Appears to be specific for EDNRB.

Application Details

Application Notes: IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Purity: IgG

Purification: Unpurified, concentrated culture supernatant.

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Arai, Nakao, Hosoda et al.: "[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]" in: Japanese circulation journal, Vol. 56 Suppl 5, pp. 1303-7, 1993 (PubMed).

Nakamuta, Takayanagi, Sakai et al.: "Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptor." in: Biochemical and biophysical research communications, Vol. 177, Issue 1, pp. 34-9, 1991 (PubMed).

Elshourbagy, Korman, Wu et al.: "Molecular characterization and regulation of the human endothelin receptors." in: The Journal of biological chemistry, Vol. 268, Issue 6, pp. 3873-9, 1993 (PubMed).

Tsutsumi, Liang, Jones: "Novel endothelin B receptor transcripts with the potential of generating a new receptor." in: Gene, Vol. 228, Issue 1-2, pp. 43-9, 1999 (PubMed).

Pingault, Girard, Bondurand et al.: "SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism." in: Human genetics, Vol. 111, Issue 2, pp. 198-206, 2002 (PubMed).