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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Endothelin Receptor Type B (EDNRB) (C-Term) antibody
|Synonyms||ETB, ETBR, ETRB, HSCR, ABCDS, HSCR2, s, ETb, ET-B, ET>B<, ETR-b, Sox10m1, AU022549, Etb, Ednra, MGC142327, EDNRB, etb, etrb, hscr, abcds, hscr2, MGC145633, ednrb, MGC147408|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||Endothelin B receptor (EDNRB)|
|Immunogen||A synthetic peptide from the c-terminal of human Endothelin B receptor (EDNRB) conjugated to an immunogenic carrier protein was used as the immunogen. The peptide is homologous in rat and mouse.|
|Description||FUNCTION: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Subcellular location: Cell membrane; Multi-pass membrane protein. Tissue specificity: Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. Also known as: Endothelin receptor non-selective type, EDNRB, ETRB.|
|Specificity||Appears to be specific for EDNRB.|
|Application Notes||IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.|
|Purification||Unpurified, concentrated culture supernatant.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Arai, Nakao, Hosoda et al.: "[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]" in: Japanese circulation journal, Vol. 56 Suppl 5, pp. 1303-7, 1993 (PubMed).
Nakamuta, Takayanagi, Sakai et al.: "Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptor." in: Biochemical and biophysical research communications, Vol. 177, Issue 1, pp. 34-9, 1991 (PubMed).
Elshourbagy, Korman, Wu et al.: "Molecular characterization and regulation of the human endothelin receptors." in: The Journal of biological chemistry, Vol. 268, Issue 6, pp. 3873-9, 1993 (PubMed).
Tsutsumi, Liang, Jones: "Novel endothelin B receptor transcripts with the potential of generating a new receptor." in: Gene, Vol. 228, Issue 1-2, pp. 43-9, 1999 (PubMed).
Pingault, Girard, Bondurand et al.: "SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism." in: Human genetics, Vol. 111, Issue 2, pp. 198-206, 2002 (PubMed).