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Details for Product No. ABIN350388

Potassium Inwardly-Rectifying Channel, Subfamily J, Member 12 (KCNJ12) (Cytoplasmic Domain) antibody

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Synonyms IRK-2, IRK2, KCNJN1, Kir2.2, Kir2.2v, hIRK, hIRK1, hkir2.2x, kcnj12x, MB-IRK2, Kir2.1, KIR2.2, IRK
»Alternatives Cytoplasmic Domain
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350388
Quantity 500 µg
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the cytoplasmic domain of human KCNJ12 (KCNJN1, Kir2.2, IRK2) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificity Appears to be specific for KCNJ12.
Purity IgG
Alternative Name KCNJ12 (KCNJN1, Kir2.2, IRK2)
Background Function: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
Tissue specificity: Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: ATP-sensitive inward rectifier potassium channel 12, Potassium channel, inwardly rectifying subfamily J member 12, Inward rectifier K(+) channel Kir2.2, Kir2.2v, IRK2, KCNJN1.
UniProt Q14500
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Wible, De Biasi, Majumder et al.: "Cloning and functional expression of an inwardly rectifying K+ channel from human atrium." in: Circulation research, Vol. 76, Issue 3, pp. 343-50, 1995 (PubMed).

Namba, Inagaki, Gonoi et al.: "Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2." in: FEBS letters, Vol. 386, Issue 2-3, pp. 211-4, 1996 (PubMed).

Gallagher, Forget: "An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene." in: The Journal of biological chemistry, Vol. 273, Issue 3, pp. 1339-48, 1998 (PubMed).

Kaibara, Ishihara, Doi et al.: "Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes." in: FEBS letters, Vol. 531, Issue 2, pp. 250-4, 2002 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Alternatives for antigen "Potassium Inwardly-Rectifying Channel, Subfamily J, Member 12 (KCNJ12)", type "Antibodies"
Hosts (15), (7)
Reactivities (12), (12), (10), (1), (1)
Applications (20), (8), (6), (3), (3), (2), (2), (2), (1)
Epitopes (5), (4), (4), (2), (1), (1), (1), (1), (1)