Potassium Inwardly-Rectifying Channel, Subfamily J, Member 12 (KCNJ12) (Cytoplasmic Domain) antibody

Details for Product No. ABIN350388
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Antigen
Synonyms IRK-2, IRK2, KCNJN1, Kir2.2, Kir2.2v, hIRK, hIRK1, hkir2.2x, kcnj12x, Kir2.1, IRK, KIR2.2, MB-IRK2
Epitope
Cytoplasmic Domain
(25), (17), (7), (5), (4), (2), (2), (1)
Reactivity
Human
(30), (21), (10), (2), (1), (1)
Host
Rabbit
(25), (21)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(44), (20), (19), (8), (8), (2), (2), (1)
Pubmed 5 references available
Quantity 500 µg
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Catalog No. ABIN350388
454.67 $
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Immunogen A synthetic peptide from the cytoplasmic domain of human KCNJ12 (KCNJN1, Kir2.2, IRK2) conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for KCNJ12.
Alternative Name KCNJ12
Background Function: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
Tissue specificity: Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: ATP-sensitive inward rectifier potassium channel 12, Potassium channel, inwardly rectifying subfamily J member 12, Inward rectifier K(+) channel Kir2.2, Kir2.2v, IRK2, KCNJN1.
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Wible, De Biasi, Majumder et al.: "Cloning and functional expression of an inwardly rectifying K+ channel from human atrium." in: Circulation research, Vol. 76, Issue 3, pp. 343-50, 1995 (PubMed).

Namba, Inagaki, Gonoi et al.: "Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2." in: FEBS letters, Vol. 386, Issue 2-3, pp. 211-4, 1996 (PubMed).

Gallagher, Forget: "An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene." in: The Journal of biological chemistry, Vol. 273, Issue 3, pp. 1339-48, 1998 (PubMed).

Kaibara, Ishihara, Doi et al.: "Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes." in: FEBS letters, Vol. 531, Issue 2, pp. 250-4, 2002 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

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