Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (C-Term) antibody

Details for Product No. ABIN350520
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Antigen
Synonyms NMDAR2B, GluN2B, MRD6, NR2B, hNR3, nmdar2b, nr2b, AW490526, Nmdar2b
Epitope
C-Term
(52), (45), (43), (38), (37), (28), (23), (23), (17), (6), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(320), (297), (256), (138), (136), (135), (70), (17), (8), (7), (4), (3), (3), (2), (2)
Host
Rabbit
(310), (59), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (11), (11), (9), (9), (9), (9), (9), (9), (9), (9), (8), (6), (6), (6), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(241), (94), (86), (82), (75), (71), (54), (38), (22), (11), (4), (1), (1)
Pubmed 5 references available
Quantity 500 μg
Options
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Catalog No. ABIN350520
454.67 $
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Immunogen A synthetic peptide from the c-terminal region of human NMDAR2B (GRIN2B) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in mouse and rat.
Isotype IgG
Specificity Specific for NMDAR2B.
Alternative Name NMDAR2B
Background Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
Subcellular location: Cell membrane, Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane, Multi-pass membrane protein. Also known as: GRIN2B, N-methyl-D-aspartate receptor subunit 3, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDE1, NR2B, NR3.
Research Area Neurology, Neurotransmitters, Receptors
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Mandich, Schito, Bellone et al.: "Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12." in: Genomics, Vol. 22, Issue 1, pp. 216-8, 1994 (PubMed).

Adams, Foldes, Kamboj: "Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein." in: Biochimica et biophysica acta, Vol. 1260, Issue 1, pp. 105-8, 1995 (PubMed).

Schito, Pizzuti, Di Maria et al.: "mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit." in: Neuroscience letters, Vol. 239, Issue 1, pp. 49-53, 1998 (PubMed).

Wu, Dowbenko, Spencer et al.: "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21477-85, 2000 (PubMed).

Munton, Tweedie-Cullen, Livingstone-Zatchej et al.: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).

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