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Details for Product No. ABIN350707

Nerve Growth Factor Receptor (NGFR) antibody

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Antigen
Synonyms CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, ngfr, wu:fb38c02, wu:fc10h01, NRH1b, fullback, nrh1, p75ntr, tnfrsf16
Reactivity
»Alternatives Rat (Rattus)
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Pubmed 4 references available
Catalog no. ABIN350707
Quantity 100 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen Nerve growth factor receptor (TNFR superfamily, member 16)
Isotype IgG1
Specificity Appears to be specific for rat p75NTR.
Purification Purified
Alternative Name p75NTR (low affinity NGF receptor, MC192)
Background Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Subunit: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: TNR16, low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, low affinity neurotrophin receptor p75NTR, Tnfrsf16, Ngfr, p75, LNGFR, RNNGFRR.
UniProt P07174
Application Notes WB, IHC, ELISA. A working concentration of 5-15 µg/ml is recommended. This antibody is suitable for use in paraformaldehyde fixed, alcohol fixed and paraffin-embedded sections. The optimal working solution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Johnson, Lanahan, Buck et al.: "Expression and structure of the human NGF receptor." in: Cell, Vol. 47, Issue 4, pp. 545-54, 1986 (PubMed).

Nemoto, Kageyama, Hagiwara et al.: "Mutation of low affinity nerve growth factor receptor gene in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats: one of the promising candidate genes for hypertension." in: Brain research, Vol. 655, Issue 1-2, pp. 267-70, 1995 (PubMed).

Sposato, Manni, Chaldakov et al.: "Streptozotocin-induced diabetes is associated with changes in NGF levels in pancreas and brain." in: Archives italiennes de biologie, Vol. 145, Issue 2, pp. 87-97, 2007 (PubMed).

Sivilia, Paradisi, DIntino et al.: "Skin homeostasis during inflammation: a role for nerve growth factor." in: Histology and histopathology, Vol. 23, Issue 1, pp. 1-10, 2007 (PubMed).

Alternatives for antigen "Nerve Growth Factor Receptor (NGFR)", type "Antibodies"
Hosts (63), (55), (12), (3), (1)
Reactivities (101), (41), (35), (20), (14), (14), (13), (11), (5), (5), (4), (3)
Applications (86), (50), (44), (39), (35), (30), (28), (20), (18), (10), (5), (4), (3), (1), (1), (1), (1)
Conjugates (7), (6), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (5), (4), (4), (4), (2), (2), (2), (1), (1), (1)
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