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Details for Product No. ABIN350707

Nerve Growth Factor Receptor (NGFR) antibody

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Antigen
Synonyms CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, ngfr, wu:fb38c02, wu:fc10h01, NRH1b, fullback, nrh1, p75ntr, tnfrsf16
Reactivity
»Alternatives All Species
Host
»Alternatives Sheep
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Pubmed 4 references available
Catalog no. ABIN350707
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen Nerve growth factor receptor (TNFR superfamily, member 16)
Specificity Specific for EGFP/GFP/Venus
Purification Purified
Alternative Name p75NTR (low affinity NGF receptor, MC192)
Background Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Subunit: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: TNR16, low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, low affinity neurotrophin receptor p75NTR, Tnfrsf16, Ngfr, p75, LNGFR, RNNGFRR.
Application Notes A working concentration of 5-15 µg/mL is recommended. This antibody is suitable for use in paraformaldehyde fixed, alcohol fixed and paraffin-embedded sections.
The optimal working solution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Johnson, Lanahan, Buck et al.: "Expression and structure of the human NGF receptor." in: Cell, Vol. 47, Issue 4, pp. 545-54, 1986 (PubMed).

Nemoto, Kageyama, Hagiwara et al.: "Mutation of low affinity nerve growth factor receptor gene in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats: one of the promising candidate genes for hypertension." in: Brain research, Vol. 655, Issue 1-2, pp. 267-70, 1995 (PubMed).

Sposato, Manni, Chaldakov et al.: "Streptozotocin-induced diabetes is associated with changes in NGF levels in pancreas and brain." in: Archives italiennes de biologie, Vol. 145, Issue 2, pp. 87-97, 2007 (PubMed).

Sivilia, Paradisi, DIntino et al.: "Skin homeostasis during inflammation: a role for nerve growth factor." in: Histology and histopathology, Vol. 23, Issue 1, pp. 1-10, 2007 (PubMed).

Alternatives for antigen "Nerve Growth Factor Receptor (NGFR)", type "Antibodies"
Hosts (97), (65), (11), (4), (1)
Reactivities (142), (73), (67), (37), (14), (14), (13), (11), (5), (5), (4), (3), (1), (1), (1)
Applications (115), (62), (56), (53), (40), (34), (31), (30), (20), (20), (5), (4), (3), (1), (1), (1), (1)
Conjugates (8), (7), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Epitopes (10), (7), (6), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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