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NGFR antibody

NGFR Reactivity: Human, Rabbit, Cat, Ferret, Monkey, Baboon FACS, IF, IHC, Diff, StM Host: Mouse Monoclonal NGFR5 unconjugated
Catalog No. ABIN6940192
  • Target See all NGFR Antibodies
    NGFR (Nerve Growth Factor Receptor (NGFR))
    Reactivity
    • 161
    • 61
    • 55
    • 28
    • 26
    • 26
    • 25
    • 20
    • 10
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Rabbit, Cat, Ferret, Monkey, Baboon
    Host
    • 93
    • 75
    • 4
    • 1
    Mouse
    Clonality
    • 93
    • 80
    Monoclonal
    Conjugate
    • 91
    • 15
    • 12
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NGFR antibody is un-conjugated
    Application
    • 107
    • 81
    • 60
    • 56
    • 48
    • 30
    • 27
    • 20
    • 20
    • 14
    • 14
    • 11
    • 9
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Differentiation (Diff), Staining Methods (StM)
    Specificity
    It recognizes a glycoprotein of 75 kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). Its epitope spans in aa 1-160 of extracellular domain of NGFR/NTR. NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75.
    No Cross-Reactivity
    Mouse (Murine), Rat (Rattus)
    Purification
    Purified by Protein A/G
    Immunogen
    NGFR from A875 melanoma cells
    Clone
    NGFR5
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product NGFR Primary Antibody
  • Application Notes

    Positive Control: Neuronal axons, Schwann cells and perineural cells of peripheral nerves or tumors of nerve sheath differentiation e. G. Schwannoma, Neurofibroma. Soma and axons of sensory neurons and ganglionic satellite cells. Melanomas.

    Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    NGFR (Nerve Growth Factor Receptor (NGFR))
    Alternative Name
    NGFR (NGFR Products)
    Synonyms
    ngfr antibody, wu:fb38c02 antibody, wu:fc10h01 antibody, CD271 antibody, Gp80-LNGFR antibody, TNFRSF16 antibody, p75(NTR) antibody, p75NTR antibody, LNGFR antibody, RNNGFRR antibody, Tnfrsf16 antibody, p75 antibody, NRH1b antibody, fullback antibody, nrh1 antibody, p75ntr antibody, tnfrsf16 antibody, p75NGFR antibody, nerve growth factor receptor antibody, neurotrophin receptor associated death domain antibody, nerve growth factor receptor S homeolog antibody, nerve growth factor receptor (TNFR superfamily, member 16) antibody, NGFR antibody, nradd antibody, Ngfr antibody, ngfr.S antibody
    Molecular Weight
    75kDa
    Gene ID
    4804
    UniProt
    P08138
    Pathways
    NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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