Sirtuin 5 (SIRT5) (C-Term) antibody

Details for Product No. ABIN358734
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Antigen
Synonyms SIRT5, sir2l5, zgc:92288, SIR2L5, sirt5-a, 0610012J09Rik, 1500032M05Rik, AV001953
Epitope
C-Term
(22), (7), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(91), (35), (26), (4), (3), (2), (2), (1), (1)
Host
Rabbit
(69), (23), (8), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(87), (37), (21), (17), (16), (12), (10), (7), (4), (3)
Pubmed 2 references available
Quantity 0.4 mL
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Catalog No. ABIN358734
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from C-terminal region of human Sirt5.
Specificity This antibody recognizes SIRT5 (C-term).
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SIRT5
Background SIRT5 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
Alternate names: NAD-dependent deacetylase sirtuin-5, SIR2-like protein 5, SIR2L5, SIRT-5, sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), sirtuin 5, sirtuin type 5, sirtuin-5
Gene ID 23408, 9606
UniProt Q9NXA8
Research Area Chromatin and Nuclear Signaling, Proteases
Application Notes ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Flow Cytometry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Sirtuin 5 (SIRT5) (C-Term) antibody anti-Sirtuin 5 (SIRT5) (C-Term) antibody
anti-Sirtuin 5 (SIRT5) (C-Term) antibody (2) anti-Sirtuin 5 (SIRT5) (C-Term) antibody (Image 2)
Background publications Frye: "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity." in: Biochemical and biophysical research communications, Vol. 260, Issue 1, pp. 273-9, 1999 (PubMed).

Frye: "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins." in: Biochemical and biophysical research communications, Vol. 273, Issue 2, pp. 793-8, 2000 (PubMed).

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