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Insulin-Degrading Enzyme (IDE) (Internal Region) antibody

Details for Product No. ABIN375106, Supplier: Login to see
Antigen
  • zgc:162603
  • IDE
  • 1300012G03Rik
  • 4833415K22Rik
  • AA675336
  • AI507533
  • INSDEGM
  • INSULYSIN
Epitope
Internal Region
33
13
13
4
3
3
2
2
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human
102
43
34
5
3
3
2
2
2
1
Host
Goat
70
40
8
Clonality
Polyclonal
Conjugate
Un-conjugated
6
5
5
4
4
4
2
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
93
49
36
23
13
3
3
2
2
1
1
Supplier
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Immunogen Peptide with sequence C-QQYNFDRDNTE, from the internal region of the protein sequence
Specificity This antibody reacts to Insulysin / Insulinase.
Cross-Reactivity (Details) Species reactivity (expected):Canine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name Insulin-Degrading Enzyme (IDE Antibody Abstract)
Background Insulin degrading enzyme (IDE) has a preferential affinity for insulin such that the presence of insulin will inhibit IDE mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma secretase cleaved APP that may function in nuclear signaling.Synonyms: Abeta-degrading protease, EC=3.4.24.56, IDE, Insulin protease, Insulinase, Insulysin
Gene ID 3416, 9606
UniProt P14735
Pathways
Application Notes Peptide ELISA: 1/32000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Insulin-Degrading Enzyme (IDE) (Internal Region) antibody (ABIN375106) anti-Insulin-Degrading Enzyme (IDE) (Internal Region) antibody
 image for anti-Insulin-Degrading Enzyme (IDE) (Internal Region) antibody (ABIN375106) anti-Insulin-Degrading Enzyme (IDE) (Internal Region) antibody (Image 2)
Background publications Zhao, Xiang, Haroutunian et al.: "Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease." in: Neurobiology of aging, Vol. 28, Issue 6, pp. 824-30, 2007 (PubMed).