Insulin-Degrading Enzyme (IDE) (Internal Region) antibody

Details for Product No. ABIN375106
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Antigen
Synonyms INSULYSIN, AA675336, AI507533, 1300012G03Rik, 4833415K22Rik, INSDEGM, zgc:162603, IDE
Epitope
Internal Region
(16), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human
(66), (38), (28), (25), (25), (24), (3)
Host
Goat
(45), (17), (14)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB)
(53), (33), (24), (14), (11), (9), (6), (6), (1)
Pubmed 1 reference available
Catalog no. ABIN375106
Quantity 0.1 mg
Price
357.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Peptide with sequence C-QQYNFDRDNTE, from the internal region of the protein sequence
Specificity This antibody reacts to Insulysin / Insulinase. Species Reactivity: Tested: Human. Expected from sequence similarity: Canine.
Purification Affinity chromatography
Alternative Name Insulin-degrading enzyme
Background Insulin degrading enzyme (IDE) has a preferential affinity for insulin such that the presence of insulin will inhibit IDE mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma secretase cleaved APP that may function in nuclear signaling.
Alternate names: Abeta-degrading protease, EC=3.4.24.56, IDE, Insulin protease, Insulinase, Insulysin
Gene ID 3416
NCBI Accession 9606
UniProt P14735
Application Notes Peptide ELISA: 1/32000. Western Blot: 0.1 - 0.3 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Insulin-Degrading Enzyme (IDE) (Internal Region) antibody anti-Insulin-Degrading Enzyme (IDE) (Internal Region) antibody
anti-Insulin-Degrading Enzyme (IDE) (Internal Region) antibody (2) anti-Insulin-Degrading Enzyme (IDE) (Internal Region) antibody (Image 2)
Background publications Zhao, Xiang, Haroutunian et al.: "Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease." in: Neurobiology of aging, Vol. 28, Issue 6, pp. 824-30, 2007 (PubMed).

Hosts (45), (17), (14)
Reactivities (66), (38), (28), (25), (25), (24), (3)
Applications (53), (33), (24), (14), (11), (9), (6), (6), (1)
Conjugates (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Epitopes (16), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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