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IDE Products

(Insulin-Degrading Enzyme (IDE))
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].

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Featured IDE Categories

IDE Antibodies

High quality antibodies with extensive validation data.

IDE ELISA Kits

Reliable ELISA kits for a wide range of species.

IDE Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IDE Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB
Validations
  • (6)
Cat. No. ABIN723680
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, FACS, IHC (p), WB
Validations
  • (4)
Cat. No. ABIN5708390
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (3)
Cat. No. ABIN334425
Quantity 100 μg
Datasheet Datasheet

Recommended IDE ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (3)
  • (1)
Cat. No. ABIN6956776
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956774
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956775
Quantity 96 tests
Datasheet Datasheet

Recommended IDE Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2723516
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093008
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3137257
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our IDE products

Jiang, Shuai, Li, Yang, Deng, Li, He, Guo, Li, He: "Protein-Bound Anthocyanin Compounds of Purple Sweet Potato Ameliorate Hyperglycemia by Regulating Hepatic Glucose Metabolism in High-Fat Diet/Streptozotocin-Induced Diabetic Mice." in: Journal of agricultural and food chemistry, Vol. 68, Issue 6, pp. 1596-1608, (2020) (PubMed).

Hafez, Ghareeb, Saleh, Abady, El Demellawy, Hussien, Abdel-Monem: "Neuroprotective effect of ipriflavone against scopolamine-induced memory impairment in rats." in: Psychopharmacology, Vol. 234, Issue 20, pp. 3037-3053, (2018) (PubMed).

Ismail, Ismail, Azmi, Bakar, Yida, Abdullah, Basri et al.: "Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high ..." in: Biomedicine & pharmacotherapy, Vol. 95, pp. 780-788, (2018) (PubMed).

Aguado-Llera, Canelles, Frago, Chowen, Argente, Arilla, Barrios: "The Protective Effects of IGF-I against β-Amyloid-related Downregulation of Hippocampal Somatostatinergic System Involve Activation of Akt and Protein Kinase A." in: Neuroscience, Vol. 374, pp. 104-118, (2018) (PubMed).

Perianes-Cachero, Canelles, Aguado-Llera, Frago, Toledo-Lobo, Carrera, Cacabelos, Chowen, Argente, Arilla-Ferreiro, Barrios: "Reduction in Aβ-induced cell death in the hippocampus of 17β-estradiol-treated female rats is associated with an increase in IGF-I signaling and somatostatinergic tone." in: Journal of neurochemistry, Vol. 135, Issue 6, pp. 1257-71, (2016) (PubMed).

Elseweidy, Amin, Atteia, Ali: "Vitamin D3 intake as regulator of insulin degrading enzyme and insulin receptor phosphorylation in diabetic rats." in: Biomedicine & pharmacotherapy, Vol. 85, pp. 155-159, (2016) (PubMed).

Kim, Lone, Saghatelian: "Analysis of the proteolysis of bioactive peptides using a peptidomics approach." in: Nature protocols, Vol. 8, Issue 9, pp. 1730-42, (2013) (PubMed).

Radulescu, Fischer, Stange, Schulze: "Promoting scientific standards in Germany." in: Science (New York, N.Y.), Vol. 328, Issue 5976, pp. 307, (2010) (PubMed).

Radulescu, Poznic, Pavelic: "Complex formation between metabolic enzymes in tumor cells: unfolding the MDR1-IDE paradigm." in: Molecular cancer therapeutics, Vol. 8, Issue 11, pp. 3171, (2009) (PubMed).

Kim, Hersh, Leissring, Ingelsson, Matsui, Farris, Lu, Hyman, Selkoe, Bertram, Tanzi: "Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7825-32, (2007) (PubMed).

Synonyms and alternative names related to IDE

insulin degrading enzyme (IDE), insulin-degrading enzyme (ide), insulin-degrading enzyme (LOC591315), insulin-degrading enzyme (CC1G_01115), insulin-degrading enzyme (Bm1_26615), insulin-degrading enzyme (PTRG_10875), metallopeptidase (SJAG_01430), insulin-degrading enzyme (EBI_21700), insulin-degrading enzyme (VDBG_06702), insulin-degrading enzyme (LOAG_08082), insulin-degrading enzyme (PGTG_04982), insulin-degrading enzyme (Tsp_00424), insulin degrading enzyme (Ide), 1300012G03Rik, 4833415K22Rik, AA675336, AI507533, IDE, INSDEGM, INSULYSIN, zgc:162603

Protein level used designations for IDE

  • insulysin
  • insulin-degrading enzyme
  • insulin-degrading enzyme-like
  • insulin protease
  • insulinase
  • Abeta-degrading protease
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