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Ubiquitin Specific Peptidase 8 (USP8) (C-Term), (AA 1058-1087) antibody

Details for Product No. ABIN388891
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Antigen
Synonyms HumORF8, UBPY, AI574262, AW557536, Ubpy, mKIAA0055
Epitope
C-Term, AA 1058-1087
(21), (12), (4), (1), (1), (1)
Reactivity
Human
(44)
Host
Rabbit
(40), (3), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(42), (24), (14), (6), (2), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN388891
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This USP8 (UBPY) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1058-1087 AA from the C-terminal region of human USP8 (UBPY).
Clone RB04288
Isotype Ig
Specificity This USP8 (UBPY) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1065~1094 amino acids from the C-terminal region of human USP8.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name USP8 (UBPY)
Background USP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structur/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.
Synonyms: Ubiquitin carboxyl-terminal hydrolase 8, Ubiquitin thiolesterase 8, Ubiquitin-specific processing protease 8, Deubiquitinating enzyme 8, hUBPy
Molecular Weight 127523 DA
Gene ID 9101
UniProt UBP8_HUMAN
Research Area Ubiquitin-related antibodies, Protein Modifications, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Ubiquitin Specific Peptidase 8 (USP8) (C-Term), (AA 1058-1087) antibody The anti-USP8 Pab (ABIN388891) is used in Western blot to detect USP8 in transfected 293T cells. Data is kindly provided by Lily Yen from University of California Davis (Davis, CA).
anti-Ubiquitin Specific Peptidase 8 (USP8) (C-Term), (AA 1058-1087) antibody (2) USP8-C1072 (ABIN388891) western blot analysis in WiDr cell line lysates (35 µg/lane).This demonstrates the USP8 antibody detected the USP8 protein (arrow).
Background publications Naviglio, Mattecucci, Matoskova et al.: "UBPY: a growth-regulated human ubiquitin isopeptidase." in: The EMBO journal, Vol. 17, Issue 12, pp. 3241-50, 1998 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN388891
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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