USP8 antibody (C-Term)

Catalog No. ABIN1536612

The Mouse Monoclonal anti-USP8 antibody (Clone 460CT35-1-6) (ABIN1536612) specifically detects USP8 in WB. The antibody is reactive with Human samples.

Quick Overview for USP8 antibody (C-Term) (ABIN1536612)

Target: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This USP8 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 460CT35-1-6

Product Details anti-USP8 Antibody

Binding Specificity: AA 1-30, C-Term

Predicted Reactivity: M

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This USP8 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the C-terminal region of human USP8.

Isotype: IgG1

Application Details

Application Notes: WB: 1:500~4000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: USP8 Antibody (C-term C1072)(Ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for USP8

Target: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Alternative Name: USP8

Background: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.

Molecular Weight: 127523

Gene ID: 9101

NCBI Accession: NP_001122082, NP_001122083, NP_005145

UniProt: P40818