Cyclin D1 (CCND1) (AA 68-97), (Ser90) antibody

Details for Product No. ABIN389146
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Antigen
Epitope
AA 68-97, Ser90
(44), (21), (15), (11), (8), (7), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(265), (98), (96), (28), (16), (9), (7), (2), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(230), (73), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(12), (10), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(246), (91), (82), (56), (55), (39), (35), (33), (20), (19), (11), (3), (3), (3), (2), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN389146
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Immunogen This Cyclin D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-97 AA from human Cyclin D1.
Clone RB8066
Isotype Ig
Specificity This Cyclin D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S90 of human Cyclin D1.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Cyclin D1
Background CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. It has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Synonyms: CCND1 protein, Cyclin D1, isoform CRA_c, cDNA, FLJ93625, Homo sapiens cyclin D1 (PRAD1: parathyroid adenomatosis 1) (CCND1),mRNA, Cyclin D1, PRAD1: parathyroid adenomatosis 1, CCND1
Pathways: Jak-STAT signaling pathway, Pathways in cancer, Non-small cell lung cancer, Measles, Focal adhesion, Wnt signaling pathway, p53 signaling pathway, Prostate cancer, Melanoma, Bladder cancer, Cell cycle, Small cell lung cancer, Colorectal cancer, Pancreatic cancer, Chronic myeloid leukemia, Endometrial cancer, Acute myeloid leukemia, Viral myocarditis, Glioma, Thyroid cancer
Molecular Weight 33729 Da
Gene ID 595
UniProt P24385
Research Area Cancer, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Cyclin D1 (CCND1) (AA 68-97), (Ser90) antibody Western blot analysis of anti-Cyclin D1 Antibody (S90) (ABIN389146) in mouse lung and bladder tissue lysates (35 µg/lane). Cyclin D1(arrow) was detected using the purified polyclonal antibody.
anti-Cyclin D1 (CCND1) (AA 68-97), (Ser90) antibody (2) Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with Cyclin D1 Antibody (S90), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Cyclin D1 (CCND1) (AA 68-97), (Ser90) antibody (3) Formalin-fixed and paraffin-embedded human Testis tissue reacted with Cyclin D1 Antibody (S90)(ABIN389146), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
Background publications Caldon, Swarbrick, Lee et al.: "The helix-loop-helix protein Id1 requires cyclin D1 to promote the proliferation of mammary epithelial cell acini." in: Cancer research, Vol. 68, Issue 8, pp. 3026-36, 2008 (PubMed).

Marsit, Black, Posner et al.: "A genotype-phenotype examination of cyclin D1 on risk and outcome of squamous cell carcinoma of the head and neck." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 8, pp. 2371-7, 2008 (PubMed).

He, Council, Feng et al.: "UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes." in: Cancer research, Vol. 68, Issue 10, pp. 3752-8, 2008 (PubMed).

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