You are viewing an incomplete version of our website. Please click to reload the website as full version.

Wnt1 Inducible Signaling Pathway Protein 3 (WISP3) (AA 305-335), (Center) antibody

Details for Product No. ABIN390189, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms si:dkey-119m7.6, WISP3, CCN6, LIBC, PPAC, PPD, ENSMUSG00000062074, Gm735, WISP-3, RGD1564120
AA 305-335, Center
(14), (8), (6), (1), (1), (1), (1)
(39), (13), (13)
(38), (1)
Clonality (Clone)
Polyclonal ()
(3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(20), (20), (17), (11), (10), (2)
Pubmed 3 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This WISP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-335 AA from the Central region of human WISP3.
Clone RB2145-2146
Isotype Ig
Specificity This WISP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human WISP3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name WISP3 (WISP3 Antibody Abstract)
Background WISP3 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP3 is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of the WISP3 gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis.
Synonyms: WNT1-inducible-signaling pathway protein 3, WISP-3, CCN6
Molecular Weight 39292 DA
Gene ID 8838
UniProt O95389
Research Area Cancer, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Wnt1 Inducible Signaling Pathway Protein 3 (WISP3) (AA 305-335), (Center) antibody (ABIN390189) Western blot analysis of anti-WISP3 Antibody (Center) (ABIN390189) in HepG2 cell line...
Immunohistochemistry (IHC) image for anti-Wnt1 Inducible Signaling Pathway Protein 3 (WISP3) (AA 305-335), (Center) antibody (ABIN390189) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Product cited in: Ji, Jia, Jia et al.: "WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-? pathways." in: British journal of cancer, Vol. 113, Issue 6, pp. 921-33, 2015 (PubMed).

Background publications Hurvitz, Suwairi, Van Hul et al.: "Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia." in: Nature genetics, Vol. 23, Issue 1, pp. 94-8, 1999 (PubMed).

Pennica, Swanson, Welsh et al.: "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 25, pp. 14717-22, 1999 (PubMed).

Catalog No. ABIN390189
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)