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Details for Product No. ABIN390189

Wnt1 Inducible Signaling Pathway Protein 3 (WISP3) (AA 305-335), (Center) antibody

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Antigen
Synonyms CCN6, LIBC, PPAC, PPD, ENSMUSG00000062074, Gm735, WISP-3, RGD1564120, si:dkey-119m7.6, WISP3
Epitope
»Alternatives AA 305-335, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 2 references available
Catalog no. ABIN390189
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This WISP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-335 AA from the Central region of human WISP3.
Clone RB2145-2146
Isotype Ig
Specificity This WISP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human WISP3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name WISP3
Background WISP3 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP3 is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of the WISP3 gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis.
Synonyms: WNT1-inducible-signaling pathway protein 3, WISP-3, CCN6
Molecular Weight 39292 DA
Gene ID 8838
UniProt O95389
Research Area Cancer, Cell Cycle, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Pennica, Swanson, Welsh et al.: "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 25, pp. 14717-22, 1999 (PubMed).

Hurvitz, Suwairi, Van Hul et al.: "Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia." in: Nature genetics, Vol. 23, Issue 1, pp. 94-8, 1999 (PubMed).

Alternatives for antigen "Wnt1 Inducible Signaling Pathway Protein 3 (WISP3)", type "Antibodies"
Hosts (21), (1)
Reactivities (22), (12), (12), (12)
Applications (11), (10), (10), (8), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (1), (1), (1)
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