WISP3 antibody (Middle Region)

Catalog No. ABIN358747

This Rabbit Polyclonal antibody specifically detects WISP3 in WB, IHC (p) and EIA. It exhibits reactivity toward Human.

Quick Overview for WISP3 antibody (Middle Region) (ABIN358747)

Target: WISP3 (Wnt1 Inducible Signaling Pathway Protein 3 (WISP3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WISP3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-WISP3 Antibody

Binding Specificity: Middle Region

Specificity: This antibody reacts to WISP3.

Purification: Affinity chromatography on Protein G

Immunogen: KLH conjugated synthetic peptide selected from the center region of human WISP3

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Western Blot: 1/50 - 1/200. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for WISP3

Target: WISP3 (Wnt1 Inducible Signaling Pathway Protein 3 (WISP3))

Alternative Name: WISP3

Background: WISP3 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP3 is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of the WISP3 gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis.Synonyms: CCN6, UNQ462/PRO790/PRO956, WISP-3, WNT1-inducible-signaling pathway protein 3

Gene ID: 8838, 9606

UniProt: O95389

Pathways: WNT Signaling, Growth Factor Binding