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Details for Product No. ABIN390286

Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (C-Term), (AA 199-235) antibody

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ABAD, CAMR, ERAB, HCD2, MHBD, HADH2, MRPP2, MRX17, MRX31, SCHAD, MRXS10, SDR5C1, 17b-HSD10, DUPXp11.22, Hadh2, 17bHSD10, Ads9, abad, camr, erab, hadh2, hcd2, hsd10, mhbd, mrpp2, mrx17, mrx31, mrxs10,  ... show more
»Alternatives C-Term, AA 199-235
»Alternatives Human, Mouse (Murine)
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 2 references available
Catalog no. ABIN390286
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This ABAD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-235 AA from the C-terminal region of human ABAD.
Clone RB6481
Isotype Ig
Specificity This ABAD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ABAD.
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ABAD
Background Amyloid b-peptide-binding alcohol dehydrogenase (ABAD) is a member of the family of short chain dehydrogenase/reductases, unique among this family, it binds amyloid b-peptide and exhibits enzymatic activity toward a wide variety of substrates including linear alcohols. In an amyloid beta-abundant environment, ABAD appears to trigger cell stress induced by the amyloid peptide.
Synonyms: hydroxyacyl-Coenzyme A dehydrogenase, type II isoform 1, 3-hydroxyacyl-CoA dehydrogenase type II, Type II HADH, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, Endoplasmic reticulum-associated amyloid beta-peptide binding protein, Short-chain type dehydrogen
Molecular Weight 26923 DA
Gene ID 3028
UniProt Q6IBS9
Research Area Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications He, Merz, Mehta et al.: "Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenase." in: The Journal of biological chemistry, Vol. 274, Issue 21, pp. 15014-9, 1999 (PubMed).

Takuma, Yao, Huang et al.: "ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 19, Issue 6, pp. 597-8, 2005 (PubMed).

Alternatives for antigen "Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10)", type "Antibodies"
Hosts (48), (24), (7)
Reactivities (77), (34), (22), (5), (5), (4), (4), (3), (1), (1)
Applications (61), (30), (27), (11), (10), (7), (7), (6), (4), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (6), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)