Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (C-Term), (AA 199-235) antibody

Details for Product No. ABIN390286
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Antigen
Epitope
C-Term, AA 199-235
(9), (7), (6), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(77), (36), (23), (3), (3), (3), (3), (3), (1)
Host
Rabbit
(52), (22), (6)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(65), (27), (25), (16), (10), (7), (6), (3), (3), (2), (2)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN390286
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Immunogen This ABAD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-235 AA from the C-terminal region of human ABAD.
Clone RB6481
Isotype Ig
Specificity This ABAD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ABAD.
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ABAD
Background Amyloid b-peptide-binding alcohol dehydrogenase (ABAD) is a member of the family of short chain dehydrogenase/reductases, unique among this family, it binds amyloid b-peptide and exhibits enzymatic activity toward a wide variety of substrates including linear alcohols. In an amyloid beta-abundant environment, ABAD appears to trigger cell stress induced by the amyloid peptide.
Synonyms: hydroxyacyl-Coenzyme A dehydrogenase, type II isoform 1, 3-hydroxyacyl-CoA dehydrogenase type II, Type II HADH, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, Endoplasmic reticulum-associated amyloid beta-peptide binding protein, Short-chain type dehydrogen
Molecular Weight 26923 DA
Gene ID 3028
UniProt Q6IBS9
Research Area Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (C-Term), (AA 199-235) antibody Western blot analysis of anti-ABAD Pab (ABIN390286) in mouse kidney tissue lysate.ABAD(arrow) was detected using the purified polyclonal antibody.
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (C-Term), (AA 199-235) antibody (2) Immunohistochemistry on Formalin-fixed and paraffin-embedded human prostate tissue. (Top)Coloration with the Anti-ABAD antibody at a 1:20 concentration. (Bottom)Antibody adsorbed to the antigen (peptide), negative control.Disappearance of cytoplasmic staining indicating the antibody is specific. Data and protocol courtesy of Marie-Hélène Levesque, Centre de Recherche du CHUL, Canada.
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (C-Term), (AA 199-235) antibody (3) ABAD Antibody (C214) (ABIN390286) western blot analysis in 293 cell line lysates (35 µg/lane).This demonstrates the ABAD antibody detected the ABAD protein (arrow).
Background publications He, Merz, Mehta et al.: "Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenase." in: The Journal of biological chemistry, Vol. 274, Issue 21, pp. 15014-9, 1999 (PubMed).

Takuma, Yao, Huang et al.: "ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 19, Issue 6, pp. 597-8, 2005 (PubMed).

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