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Details for Product No. ABIN391058

Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) (AA 265-295), (Center) antibody

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Antigen
Synonyms AMPK, AMPK2, AMPKa2, PRKAA, Ampk, Ampka2, A830082D05, AMPKalpha2, 2310008I11Rik, AMPKA2, ampk, ampk2, prkaa, prkaa1, PRKAA2
Epitope
»Alternatives AA 265-295, Center
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN391058
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This AMPK gamma (PRKAG1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-295 AA from the Central region of human AMPK gamma (PRKAG1).
Clone RB3173
Isotype Ig
Specificity This PRKAG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273~303 amino acids from the center region of human PRKAG1.
Predicted Reactivity Cow (Bovine),Pig (Porcine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name AMPK gamma (PRKAG1)
Background PRKAG1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK.
Synonyms: 5'-AMP-activated protein kinase, gamma-1 subunit, AMPK gamma-1 chain, AMPKg
UniProt AAKG_HUMAN
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
Expiry Date 6 months
Background publications Stapleton, Woollatt, Mitchelhill et al.: "AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location." in: FEBS letters, Vol. 409, Issue 3, pp. 452-6, 1997 (PubMed).

Hamilton, Stapleton, ODonnell et al.: "An activating mutation in the gamma1 subunit of the AMP-activated protein kinase." in: FEBS letters, Vol. 500, Issue 3, pp. 163-8, 2001 (PubMed).

Minokoshi, Alquier, Furukawa et al.: "AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus." in: Nature, Vol. 428, Issue 6982, pp. 569-74, 2004 (PubMed).

Alternatives for antigen "Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2)", type "Antibodies"
Hosts (124), (9), (3)
Reactivities (118), (83), (77), (29), (25), (13), (12), (12)
Applications (84), (50), (48), (22), (19), (12), (10), (6), (4), (2), (2), (1), (1), (1), (1), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (1)
Epitopes (26), (15), (12), (12), (12), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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