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Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) (AA 265-295), (Center) antibody

Details for Product No. ABIN391058
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Antigen
Epitope
AA 265-295, Center
(38), (16), (12), (12), (12), (8), (8), (6), (5), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(158), (83), (77), (27), (25), (13), (12), (12), (1)
Host
Rabbit
(157), (16), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(9), (9), (9), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(121), (73), (50), (38), (24), (16), (12), (10), (3), (2), (2), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN391058
291.50 $
Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This AMPK gamma (PRKAG1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-295 AA from the Central region of human AMPK gamma (PRKAG1).
Clone RB3173
Isotype Ig
Specificity This PRKAG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273~303 amino acids from the center region of human PRKAG1.
Predicted Reactivity Cow (Bovine),Pig (Porcine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name AMPK gamma (PRKAG1)
Background PRKAG1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK.
Synonyms: 5'-AMP-activated protein kinase, gamma-1 subunit, AMPK gamma-1 chain, AMPKg
UniProt AAKG_HUMAN
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) (AA 265-295), (Center) antibody The anti-PRKAG1 Pab (ABIN391058) is used in Western blot to detect PRKAG1 in mouse heart tissue lysate.
anti-Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) (AA 265-295), (Center) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
anti-Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2) (AA 265-295), (Center) antibody (3) Formalin-fixed and paraffin-embedded human testis tissue reacted with PRKAG1 Antibody (Center) (ABIN391058), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Stapleton, Woollatt, Mitchelhill et al.: "AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location." in: FEBS letters, Vol. 409, Issue 3, pp. 452-6, 1997 (PubMed).

Hamilton, Stapleton, ODonnell et al.: "An activating mutation in the gamma1 subunit of the AMP-activated protein kinase." in: FEBS letters, Vol. 500, Issue 3, pp. 163-8, 2001 (PubMed).

Minokoshi, Alquier, Furukawa et al.: "AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus." in: Nature, Vol. 428, Issue 6982, pp. 569-74, 2004 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN391058
291.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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