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PRKAA2 Products

(Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2))

Categories

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].

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Featured PRKAA2 Categories

PRKAA2 Antibodies

High quality antibodies with extensive validation data.

PRKAA2 ELISA Kits

Reliable ELISA kits for a wide range of species.

PRKAA2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PRKAA2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Monkey
Application ELISA, FACS, ICC, IHC, Neut, WB
Validations
  • (7)
Cat. No. ABIN5611223
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse
Application ICC, IF, IP, IHC (p), WB
Validations
  • (3)
  • (5)
Cat. No. ABIN2855639
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF, PLA, RNAi, ELISA, WB
Validations
  • (6)
Cat. No. ABIN519168
Quantity 100 μg
Datasheet Datasheet

Recommended PRKAA2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969726
Quantity 96 tests
Datasheet Datasheet
Reactivity Pig
Analytical Method
Validations
Cat. No. ABIN1119511
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1119510
Quantity 96 tests
Datasheet Datasheet

Recommended PRKAA2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (2)
Cat. No. ABIN5569698
Quantity 5 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3088403
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3136256
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PRKAA2 products

Gao, Yuan, Wang, Lei, Shen, Cui, Zhang, Ding, Lu: "Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase α2." in: Redox biology, Vol. 28, pp. 101345, (2020) (PubMed).

Derkach, Zakharova, Zorina, Bakhtyukov, Romanova, Bayunova, Shpakov: "The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect." in: PLoS ONE, Vol. 14, Issue 3, pp. e0213779, (2019) (PubMed).

Zhang, Zhang, Zhou, Fu, Michal, Ji, Du, Davis, Jiang: "Alternative polyadenylation drives genome-to-phenome information detours in the AMPKα1 and AMPKα2 knockout mice." in: Scientific reports, Vol. 8, Issue 1, pp. 6462, (2018) (PubMed).

Li, Sharma, Yin, Tan, Xiao: "Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD‑induced obese mice." in: Molecular medicine reports, Vol. 16, Issue 1, pp. 680-686, (2017) (PubMed).

Liu, Xiao, Han, Zhang, Lee, Wang, Lee, Zhuang, Chen, Lin, Wang, Liang, Gan: "LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress." in: Nature cell biology, Vol. 18, Issue 4, pp. 431-42, (2016) (PubMed).

Fu, Zhu, Dodson, Du: "AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration." in: The Journal of biological chemistry, Vol. 290, Issue 44, pp. 26445-56, (2015) (PubMed).

Jaitovich, Angulo, Lecuona, Dada, Welch, Cheng, Gusarova, Ceco, Liu, Shigemura, Barreiro, Patterson, Nader, Sznajder: "High CO2 levels cause skeletal muscle atrophy via AMP-activated kinase (AMPK), FoxO3a protein, and muscle-specific Ring finger protein 1 (MuRF1)." in: The Journal of biological chemistry, Vol. 290, Issue 14, pp. 9183-94, (2015) (PubMed).

Hindupur, Balaji, Saxena, Pandey, Sravan, Heda, Kumar, Mukherjee, Dey, Rangarajan: "Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells." in: Breast cancer research : BCR, Vol. 16, Issue 4, pp. 420, (2015) (PubMed).

Wang, Zhang, Zhang, Liang, Zhu, Lee, Viollet, Xia, Zhang, Zou: "Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo." in: Nature medicine, Vol. 18, Issue 6, pp. 902-10, (2012) (PubMed).

Lin, Kiihl, Suhail, Liu, Chou, Kuang, Lu, Khor, Lin, Bader, Irizarry, Boeke: "Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK." in: Nature, Vol. 482, Issue 7384, pp. 251-5, (2012) (PubMed).

Synonyms and alternative names related to PRKAA2

protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2), protein kinase AMP-activated catalytic subunit alpha 2 (Prkaa2), protein kinase, AMP-activated, alpha 2 catalytic subunit (Prkaa2), protein kinase, AMP-activated, alpha 2 catalytic subunit S homeolog (prkaa2.S), protein kinase, AMP-activated, alpha 2 catalytic subunit (prkaa2), 2310008I11Rik, A830082D05, AMPK, Ampk, ampk, AMPK2, ampk2, AMPKa2, Ampka2, AMPKA2, AMPKalpha2, PRKAA, prkaa, prkaa1, PRKAA2

Protein level used designations for PRKAA2

  • 5'-AMP-activated protein kinase catalytic subunit alpha-2
  • 5'-AMP-activated protein kinase, catalytic alpha-2 chain
  • ACACA kinase
  • AMPK subunit alpha-2
  • AMPK-alpha-2 chain
  • HMGCR kinase
  • acetyl-CoA carboxylase kinase
  • hydroxymethylglutaryl-CoA reductase kinase
  • AMP-activated protein kinase
  • AMPK alpha-2 chain
  • AMP-activated protein kinase alpha-2 variant B
  • AMP-activated protein kinase alpha 2
  • protein kinase AMP-activated alpha 2 catalytic subunit
  • SNF1-like protein AMPK
  • 5'-AMP-activated protein kinase alpha-2 catalytic subunit
  • AMPKalpha2
  • ampka2
  • AMP-activated protein kinase alpha 2 catalytic subunit
  • protein kinase, AMP-activated, alpha 2 catalytic subunit
  • AMPK-activated protein kinase alpha-2 subunit
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