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Details for Product No. ABIN391458

Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 299-330), (Center) antibody

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Antigen
Synonyms
CAK, CD167, DDR, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE, Cak, Nep, CD167a, AI323681, 6030432F18, DDR1, CG11573, CG13984, CG13985, CG33531, CG9488, CG9490, CT33540, Dmel\\CG33531, Dmel ... show more
Epitope
»Alternatives AA 299-330, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
Pubmed 2 references available
Catalog no. ABIN391458
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This DDR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-330 AA from the Central region of human DDR1.
Clone RB14442
Isotype Ig
Specificity This DDR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307~337 amino acids from the Center of human DDR1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name DDR1
Background Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. DDR1 is an RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. It belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis show that expression of DDR1 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.
Synonyms: Epithelial discoidin domain-containing receptor 1 [Precursor], Epithelial discoidin domain receptor 1, Tyrosine kinase DDR, Discoidin receptor tyrosine kinase, Tyrosine-protein kinase CAK, Cell adhesion kinase, TRK E, Protein-tyrosine kinase RTK 6, HGK2,
Molecular Weight 101128 DA
Gene ID 780
UniProt Q08345
Research Area Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50,IF : 1:10-50,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Johnson, Edman, Rutter: "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 12, pp. 5677-81, 1993 (PubMed).

Sakuma, Saya, Tada et al.: "Receptor protein tyrosine kinase DDR is up-regulated by p53 protein." in: FEBS letters, Vol. 398, Issue 2-3, pp. 165-9, 1997 (PubMed).

Alternatives for antigen "Discoidin Domain Receptor tyrosine Kinase 1 (DDR1)", type "Antibodies"
Hosts (60), (11), (1)
Reactivities (71), (35), (34), (13), (12), (1)
Applications (43), (33), (20), (19), (11), (3), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (16), (10), (9), (5), (4), (2), (1)
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