Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 299-330), (Center) antibody

Details for Product No. ABIN391458
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Antigen
Synonyms
CG11573, CG13984, CG13985, CG33531, CG9488, CG9490, CT33540, DDR, Dmel\\CG33531, Dmel_CG13984, 6030432F18, AI323681, CD167a, Cak, Nep, PTK3A, CAK, CD167, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, RTK6, TR ... show more
CG11573, CG13984, CG13985, CG33531, CG9488, CG9490, CT33540, DDR, Dmel\\CG33531, Dmel_CG13984, 6030432F18, AI323681, CD167a, Cak, Nep, PTK3A, CAK, CD167, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, RTK6, TRKE, Drd1, PTK3D show less
Epitope
AA 299-330, Center
(20), (15), (12), (10), (8), (7), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(104), (41), (40), (13), (12), (1)
Host
Rabbit
(90), (13), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
(68), (52), (21), (21), (20), (5), (2), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN391458
291.50 $
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Immunogen This DDR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-330 AA from the Central region of human DDR1.
Clone RB14442
Isotype Ig
Specificity This DDR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307~337 amino acids from the Center of human DDR1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name DDR1
Background Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. DDR1 is an RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. It belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis show that expression of DDR1 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.
Synonyms: Epithelial discoidin domain-containing receptor 1 [Precursor], Epithelial discoidin domain receptor 1, Tyrosine kinase DDR, Discoidin receptor tyrosine kinase, Tyrosine-protein kinase CAK, Cell adhesion kinase, TRK E, Protein-tyrosine kinase RTK 6, HGK2,
Molecular Weight 101128 DA
Gene ID 780
UniProt Q08345
Research Area Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 299-330), (Center) antibody Western blot analysis of DDR1 (arrow) using rabbit polyclonal DDR1 Antibody (Center)(ABIN391458).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the DDR1 gene (Lane 2) (Origene Technologies).
Background publications Johnson, Edman, Rutter: "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 12, pp. 5677-81, 1993 (PubMed).

Sakuma, Saya, Tada et al.: "Receptor protein tyrosine kinase DDR is up-regulated by p53 protein." in: FEBS letters, Vol. 398, Issue 2-3, pp. 165-9, 1997 (PubMed).

Validation Images
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